Ginsenoside F2 Reduces Hair Loss by Controlling Apoptosis Through the Sterol Regulatory Element-Binding Protein Cleavage Activating Protein and Transforming Growth Factor-β Pathways in a Dihydrotestosterone-Induced Mouse Model

In the 2014 study, ginsenoside F2 was found to significantly reduce hair loss in a DHT-induced mouse model by inhibiting apoptosis pathways. The substance increased cell proliferation rates by 48% in DHT-treated human hair cells, compared to a 12% increase by finasteride. Ginsenoside F2 also decreased the expression of TGF-β2 and other proteins associated with hair loss, and in vivo tests with C57BL/6 mice demonstrated improved hair growth, density, and thickness over finasteride treatment. The study, which used 10 mice per treatment group, concluded that ginsenoside F2 could be a potent agent for preventing hair loss and promoting hair growth, potentially through its effects on the SCAP and TGF-β pathways. This research was supported by the Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries.