Effect of Marine-Derived Saccharides on Human Skin Fibroblasts and Dermal Papilla Cells

May 2023 in “ Marine Drugs ”

Aleksandra Augustyniak, Helena McMahon

marine-derived saccharides L-fucose chondroitin sulphate disaccharide dermal fibroblasts dermal papilla cells collagen elastin hair growth alkaline phosphatase glycosaminoglycans marine saccharides fucose chondroitin fibroblasts papilla cells hair cycle GAGs

Studysummary The researchers reported that marine-derived saccharides, specifically L-fucose and chondroitin sulphate disaccharide, supported skin and hair health by promoting cellular proliferation, enhancing extracellular matrix production, and aiding the hair cycle's growth phase, potentially minimizing aging effects.

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The study examined the effects of marine-derived saccharides, L-fucose and chondroitin sulphate disaccharide, on skin and hair health. These compounds were found to promote the proliferation of dermal fibroblasts and dermal papilla cells, which are essential for skin and hair growth. They also increased the production of collagen and elastin, contributing to skin firmness and elasticity, and supported the growth phase of the hair cycle. The saccharides also increased the production of alkaline phosphatase, an enzyme associated with hair growth, and glycosaminoglycans, which are abundant in the hair follicle during the hair growth phase. However, the combined use of the saccharides was less effective in enhancing collagen production. The study concluded that L-fucose and chondroitin sulphate disaccharide could potentially be used to minimize the effects of aging on skin and hair.

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