Hair Growth-Promoting Effects of Sargassum Glaucescens Oligosaccharides Extracts

March 2022 in “ Journal of The Taiwan Institute of Chemical Engineers ”

Chia-Hui Huang, Chih‐Mao Huang, Chao‐Chun Yang, Tse‐Min Lee, Jo‐Shu Chang

Sargassum glaucescens fucoidan polysaccharide dermal papilla cells Insulin-like growth factor IGF-1 Lymphoid enhancer factor LEF-1 hair growth cell proliferation microwave-assisted high-pressure water extraction subcritical water extraction brown seaweed growth factor

Studysummary This study found that fucoidan extracts from Sargassum glaucescens, particularly oligo-fucoidans, promoted hair growth and increased related gene expression in human dermal papilla cells and mice models.

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The study "Hair growth-promoting effects of Sargassum glaucescens oligosaccharides extracts" investigated the effects of fucoidan, a polysaccharide extracted from Sargassum glaucescens, a type of brown seaweed found in Taiwan, on hair growth. The researchers used microwave-assisted high-pressure water extraction and subcritical water extraction to obtain the fucoidan. The study found that low molecular weight fucoidan promoted cell proliferation and upregulated Insulin-like growth factor (IGF)-1 and Lymphoid enhancer factor (LEF)-1 expression in dermal papilla cells, which are key factors in hair growth. The fucoidan extracts also demonstrated hair growth-promoting activity in mice model tests. The study concluded that Sargassum fucoidan, particularly those with lower molecular weight, effectively enhanced dermal papilla cell proliferation and growth factor-related genes expression, promoting hair growth.

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