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Did you mean Lymphoid Enhancer-Binding Factor 1?

Glossary Lymphoid Enhancer-Binding Factor 1

protein regulating gene expression in immune cells and hair follicles

Lymphoid Enhancer-Binding Factor 1 (LEF1) is a protein that plays a crucial role in the regulation of gene expression, particularly in the development and function of immune cells and hair follicles. It is part of the Wnt signaling pathway, which is important for cell growth, differentiation, and tissue regeneration. In the context of hair biology, LEF1 is involved in the formation and cycling of hair follicles, and its dysregulation can contribute to conditions like alopecia.

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Lymphoid Enhancer-Binding Factor-1 Interacts with the DNA-Binding Domain of the Vitamin D Receptor

research Lymphoid Enhancer-binding Factor-1 (LEF1) Interacts with the DNA-binding Domain of the Vitamin D Receptor

37 citations , April 2011 in “Journal of Biological Chemistry”

This study discovered a novel interaction between the vitamin D receptor and LEF1, essential for normal Wnt signaling in keratinocytes, which is crucial for regular hair cycling.

research TERT/BMI1-transgenic human dermal papilla cells enhance murine hair follicle formation in vivo

1 citations , March 2022 in “Journal of Dermatological Science”

This study concluded that overexpressing TERT and BMI1 in cultured human dermal papilla cells extended their lifespan and enhanced their ability to induce hair growth in mice.

research Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages during Skin Development

318 citations , October 1998 in “The Journal of Cell Biology”

This study found that ectopic expression of the lymphoid-enhancer factor can induce K17 protein in the skin, suggesting a link between skin development and wound repair processes in mice.

research Hair growth-promoting effects of Sargassum glaucescens oligosaccharides extracts

8 citations , March 2022 in “Journal of The Taiwan Institute of Chemical Engineers”

This study found that fucoidan extracts from Sargassum glaucescens, particularly oligo-fucoidans, promoted hair growth and increased related gene expression in human dermal papilla cells and mice models.

LncRNA-599547 Contributes to the Inductive Property of Dermal Papilla Cells in Cashmere Goats Through miR-15b-5p/Wnt10b Axis

research LncRNA-599547 contributes the inductive property of dermal papilla cells in cashmere goat through miR-15b-5p/Wnt10b axis

7 citations , August 2020 in “Animal biotechnology”

This study found that lncRNA-599547 positively regulates the expression of the Wnt10b gene by interacting with miR-15b-5p, enhancing the inductive property of dermal papilla cells in cashmere goats.

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