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Glossary LIM Homeobox 2

gene encoding a protein crucial for hair follicle development

LIM Homeobox 2 (Lhx2) is a gene that encodes a transcription factor, which is a type of protein that helps control the activity of other genes. It plays a crucial role in the development of various tissues, including the brain and hair follicles. In the context of hair, Lhx2 is essential for the proper formation and cycling of hair follicles, making it significant in studies related to hair growth and conditions like alopecia.

Research

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research 3D-Printed degradable hair follicle hanging drop scaffolds integrated with tissue engineered skin promotes hair follicle regeneration in vitro

February 2025 in “International Journal of Bioprinting”

This study constructed a 3D-printed scaffold using sodium alginate, gelatin, and alginate lyase hydrogel, which supports hair follicle regeneration in artificial skin, suggesting a promising strategy for tissue-engineered skin with functional appendages.

research Highly Upregulated Lhx2 in the Foxn1−/− Nude Mouse Phenotype Reflects a Dysregulated and Expanded Epidermal Stem Cell Niche

6 citations , May 2013 in “PloS one”

This study found that the Foxn1(-/-) nude phenotype significantly influences epithelial progeny in skin, with notable changes in stem cell niches not achievable in other models.

research Gene expression patterns during palatal shelf fusion

August 2004 in “Journal of the American College of Surgeons”

This study found that endothelial cells under serum deprivation significantly upregulated genes related to inflammation and coagulation, which may impact outcomes in tissue transfer procedures.

research Hoxc13 mutant mice lack external hair

245 citations , January 1998 in “Genes & Development”

This study found that Hoxc13 mutations in mice cause defects in hair, nail, and tongue structures, with the most noticeable issue being brittle hair leading to alopecia.

research LHX2: a transcription factor in development, homeostasis, repair, and disease

June 2026 in “Frontiers in Cell and Developmental Biology”

This review synthesizes the diverse roles of the transcription factor LHX2 in development, tissue maintenance, and injury repair across various organ systems, highlighting its potential therapeutic applications and significance in regenerative medicine, particularly in developmental disorders and tissue regeneration.

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