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    Glossary LIM Homeobox 2

    gene encoding a protein crucial for hair follicle development

    LIM Homeobox 2 (Lhx2) is a gene that encodes a transcription factor, which is a type of protein that helps control the activity of other genes. It plays a crucial role in the development of various tissues, including the brain and hair follicles. In the context of hair, Lhx2 is essential for the proper formation and cycling of hair follicles, making it significant in studies related to hair growth and conditions like alopecia.

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    1. 3D-Printed degradable hair follicle hanging drop scaffolds integrated with tissue engineered skin promotes hair follicle regeneration in vitro International Journal of Bioprinting · 2025
    2. Highly Upregulated Lhx2 in the Foxn1−/− Nude Mouse Phenotype Reflects a Dysregulated and Expanded Epidermal Stem Cell Niche PloS one · 2013 · 6 citations
    3. Gene expression patterns during palatal shelf fusion Journal of the American College of Surgeons · 2004
    4. <i>Hoxc13</i> mutant mice lack external hair Genes & Development · 1998 · 245 citations
    5. LHX2: a transcription factor in development, homeostasis, repair, and disease Frontiers in Cell and Developmental Biology · 2026
    6. miR-29a-5p Inhibits Prenatal Hair Placode Formation Through Targeting EDAR by ceRNA Regulatory Network Frontiers in Cell and Developmental Biology · 2022
    7. Bone morphogenetic protein-2 (BMP-2) transactivates Dlx3 through Smad1 and Smad4: alternative mode for Dlx3 induction in mouse keratinocytes Nucleic Acids Research · 2002 · 79 citations
    8. Wound Healing Impairment in Type 2 Diabetes Model of Leptin-Deficient Mice—A Mechanistic Systematic Review International Journal of Molecular Sciences · 2022 · 10 citations
    9. Aconiti Lateralis Preparata Radix Activates the Proliferation of Mouse Bone Marrow Mesenchymal Stem Cells and Induces Osteogenic Lineage Differentiation through the Bone Morphogenetic Protein-2/Smad-Dependent Runx2 Pathway Evidence-based Complementary and Alternative Medicine · 2013 · 18 citations
    10. Fusarium sp. Strain K-23 Alleviates Salt Stress in Arabidopsis thaliana Through its Root Hair Growth-Promoting Effect Journal of Plant Growth Regulation · 2024
    11. Food and medicine homology: a potential nutritional intervention strategy for post-acute COVID-19 syndrome Frontiers in Pharmacology · 2025 · 1 citations
    12. Hair follicle-derived mesenchymal stem cells decrease alopecia areata mouse hair loss and reduce inflammation around the hair follicle Stem Cell Research & Therapy · 2021 · 11 citations
    13. Roles for Msx and Dlx homeoproteins in vertebrate development Gene · 2000 · 234 citations
    14. PDGFA in Cashmere Goat: A Motivation for the Hair Follicle Stem Cells to Activate Animals · 2019 · 19 citations
    15. Genetic hair and nail disorders Clinics in dermatology · 2005 · 37 citations
    16. Hair in health and disease: an introduction Wageningen Academic Publishers eBooks · 2012 · 3 citations
    17. Skin and hair: models for exploring organ regeneration Human Molecular Genetics · 2008 · 35 citations
    18. Stem cell dynamics, migration and plasticity during wound healing Nature Cell Biology · 2018 · 211 citations
    19. The roles of Wnt/β‐catenin pathway in tissue development and regenerative medicine Journal of Cellular Physiology · 2017 · 89 citations
    20. Small molecules and small molecule drugs in regenerative medicine Drug Discovery Today · 2013 · 51 citations
    21. Roles of Wnt7a in embryo development, tissue homeostasis, and human diseases Journal of Cellular Biochemistry · 2019 · 16 citations
    22. Maternal PPARγ protects nursing neonates by suppressing the production of inflammatory milk Genes & Development · 2007 · 102 citations
    23. Costunolide—A Bioactive Sesquiterpene Lactone with Diverse Therapeutic Potential International Journal of Molecular Sciences · 2019 · 75 citations
    24. The Biology and Genomics of Human Hair Follicles: A Focus on Androgenetic Alopecia International Journal of Molecular Sciences · 2024
    25. Differences in Expression of Specific Biomarkers Distinguish Human Beard from Scalp Dermal Papilla Cells Journal of Investigative Dermatology · 2006 · 41 citations
    26. Bioengineering skin using mechanisms of regeneration and repair Biomaterials · 2007 · 202 citations
    27. Unraveling the Molecular Mechanisms of Hair and Nail Genodermatoses Archives of Dermatology · 2001 · 23 citations
    28. Somatic stem cell heterogeneity: diversity in the blood, skin and intestinal stem cell compartments Nature Reviews Molecular Cell Biology · 2015 · 137 citations
    29. The Critical Roles of Serum/Glucocorticoid-Regulated Kinase 3 (SGK3) in the Hair Follicle Morphogenesis and Homeostasis American Journal of Pathology · 2006 · 9 citations
    30. An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities Frontiers in Cell and Developmental Biology · 2020 · 23 citations