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GlossaryCCCTC-binding factor

protein regulating 3D genome structure and gene expression

The CCCTC-binding factor, commonly known as CTCF, is a protein that plays a crucial role in regulating the 3D structure of the genome. It acts as an insulator, controlling the interactions between different regions of DNA and ensuring that genes are expressed in the right cells at the right times. This regulation is essential for maintaining normal cellular functions and preventing diseases such as cancer.

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DNA Dioxygenases Tet2/3 Regulate Gene Promoter Accessibility and Chromatin Topology in Lineage-Specific Loci to Control Epithelial Differentiation

research DNA Dioxygenases Tet2/3 Regulate Gene Promoter Accessibility and Chromatin Topology in Lineage-Specific Loci to Control Epithelial Differentiation

3 citations , January 2023 in “Science advances”

The enzymes Tet2 and Tet3 are important for skin cell development and hair growth.

research Epidermal Growth Factor, Innovation and Safety

10 citations , October 2015 in “Medicina Clínica (english Edition)”

Recombinant human epidermal growth factor is versatile, effective, and safe for long-term skin and mucosal treatments.

research From Bedside to Bench: Regulation of Host Factors in SARS-CoV-2 Infection

4 citations , April 2021 in “Experimental and Molecular Medicine”

The conclusion is that certain genetic factors and blood types may affect COVID-19 severity, but changes in ACE2 and TMPRSS2 genes are not clearly linked to it.

research Selection Signatures in Goats Reveal a Novel Deletion Mutant Underlying Cashmere Yield and Diameter

November 2022 in “Gigascience”

A specific genetic deletion in goats affects cashmere yield and thickness.

research How a Bird Gets Its Feathers: Insights from Chromatin Looping

3 citations , June 2020 in “Developmental Cell”

Feather patterns are influenced by enhancers and chromatin looping, and the structure of protein complexes important for hair growth has been detailed.

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