LncRNA-599547 Contributes to the Inductive Property of Dermal Papilla Cells in Cashmere Goats Through miR-15b-5p/Wnt10b Axis

August 2020 in “ Animal biotechnology ”

Rong Yin, Suping Zhao, Ze Y. Wang, Yanbing Zhu, Rong Yin, Man Bai, Yi Fan, Wei Wang, Wen Bai

lncRNA-599547 dermal papilla cells DPCs anagen phase telogen phase ALP LEF1 chi-miR-15b-5p Wnt10b hair follicle development promoter methylation long non-coding RNA hair growth phase alkaline phosphatase lymphoid enhancer-binding factor 1 microRNA-15b-5p Wnt signaling pathway gene regulation

Studysummary This study found that lncRNA-599547 positively regulates the expression of the Wnt10b gene by interacting with miR-15b-5p, enhancing the inductive property of dermal papilla cells in cashmere goats.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study identified a long non-coding RNA (lncRNA-599547) in the secondary hair follicle of cashmere goats and investigated its role in the inductive properties of dermal papilla cells (DPCs). The expression of lncRNA-599547 was significantly higher during the anagen phase of hair growth compared to the telogen phase. Overexpression of lncRNA-599547 in DPCs led to increased expression of ALP and LEF1, while silencing it resulted in decreased expression of these markers, indicating its regulatory role in DPC function. The study also demonstrated that lncRNA-599547 interacts with chi-miR-15b-5p and modulates the expression of Wnt10b, a gene involved in hair follicle development, at the post-transcriptional level without affecting its promoter methylation. These findings suggest that lncRNA-599547 acts by sponging miR-15b-5p to regulate Wnt10b expression, thereby enhancing the inductive capacity of DPCs in cashmere goats.

View this study on tandfonline.com →

Discuss this study in the Community →

Research cited in this study

19 / 19 results

research Use of Extracellular Matrix Hydrogel from Human Placenta to Restore Hair-Inductive Potential of Dermal Papilla Cells

31 citations , August 2019 in “Regenerative Medicine”

This study found that the human placenta extracellular matrix hydrogel restored the hair-inductive capacity of high-passaged dermal papilla cells, enabling them to regenerate new hair follicles when co-grafted with mouse epidermal cells.

research An Integrated Analysis of Cashmere Fineness lncRNAs in Cashmere Goats

26 citations , April 2019 in “Genes”

In this study, researchers identified novel long non-coding RNAs related to cashmere fineness in goats, highlighting a potential regulatory network involving lncRNA XLOC_008679 and its target gene KRT35.

research Flavonoid Silibinin Increases Hair-Inductive Property Via Akt and Wnt/β-Catenin Signaling Activation in 3-Dimensional Spheroid Cultured Human Dermal Papilla Cells

29 citations , February 2019 in “Journal of Microbiology and Biotechnology”

This study found that silibinin may promote hair growth by increasing proliferation and activating the AKT and Wnt/β-catenin signaling pathways in 3D cultured human dermal papilla spheroids.

research Hypoxia Improves Hair Inductivity of Dermal Papilla Cells via Nuclear NADPH Oxidase 4-Mediated Reactive Oxygen Species Generation

25 citations , January 2019 in “British Journal of Dermatology”

Low oxygen levels can make hair-growing cells better at growing hair through a process involving reactive oxygen species.

LncRNA-000133 from Secondary Hair Follicle of Cashmere Goat: Identification, Regulatory Network, and Its Effects on Inductive Property of Dermal Papilla Cells

research LncRNA-000133 from Secondary Hair Follicle of Cashmere Goat: Identification, Regulatory Network, and Its Effects on Inductive Property of Dermal Papilla Cells

18 citations , January 2019 in “Animal Biotechnology”

This study found that lncRNA-000133 may play a role in secondary hair follicle reconstruction and cashmere fiber growth in goats, potentially through its interaction with the methylation of its regulatory region and dermal papilla cells.

research Integrative Analysis Reveals ncRNA-Mediated Molecular Regulatory Network Driving Secondary Hair Follicle Regression in Cashmere Goats

50 citations , March 2018 in “BMC Genomics”

This study expands knowledge of non-coding RNAs in goats and other mammals, enhancing understanding of their roles in hair follicle growth and regression.

Titrated Extract of Centella Asiatica Increases Hair Inductive Property Through Inhibition of STAT Signaling Pathway in Three-Dimensional Spheroid Cultured Human Dermal Papilla Cells

research Titrated Extract of Centella Asiatica Increases Hair Inductive Property Through Inhibition of STAT Signaling Pathway in Three-Dimensional Spheroid Cultured Human Dermal Papilla Cells

13 citations , October 2017 in “Bioscience, Biotechnology, and Biochemistry”

This study found that a titrated extract of Centella asiatica enhanced the hair growth potential of 3D spheroid cultured human dermal papilla cells.

research Integrated Analysis of Coding Genes and Non-Coding RNAs During Hair Follicle Cycle of Cashmere Goat (Capra Hircus)

129 citations , October 2017 in “BMC Genomics”

This study identified potential ceRNA regulatory networks in cashmere goat hair follicle cycling, expanding understanding of lncRNA and miRNA biology and annotation of the goat genome.

LncRNAs in Secondary Hair Follicle of Cashmere Goat: Identification, Expression, and Their Regulatory Network in Wnt Signaling Pathway

research LncRNAs in Secondary Hair Follicle of Cashmere Goat: Identification, Expression, and Their Regulatory Network in Wnt Signaling Pathway

25 citations , August 2017 in “Animal Biotechnology”

This study identified and characterized several long noncoding RNAs in Cashmere goats, revealing complex regulatory roles in hair follicle development and growth, particularly within the Wnt signaling pathway.

research Activating Beta-Catenin Signaling in CD133-Positive Dermal Papilla Cells Increases Hair Inductivity

23 citations , June 2016 in “FEBS Journal”

The study found that up-regulating β-catenin signaling in CD 133-positive dermal papilla cells enhanced their ability to promote hair follicle regeneration both in vitro and in vivo.

Fibroblast Growth Factor 5-Short (FGF5s) Inhibits the Activity of FGF5 in Primary and Secondary Hair Follicle Dermal Papilla Cells of Cashmere Goats

research Fibroblast Growth Factor 5-Short (FGF5s) Inhibits the Activity of FGF5 in Primary and Secondary Hair Follicle Dermal Papilla Cells of Cashmere Goats

42 citations , September 2015 in “Gene”

This study demonstrated that FGF5s acts as an inhibitor of FGF5 in regulating hair growth cycles in cashmere goat dermal papilla cells.

research Wnt1a Maintains Characteristics of Dermal Papilla Cells That Induce Mouse Hair Regeneration in a 3D Preculture System

23 citations , June 2015 in “Journal of Tissue Engineering and Regenerative Medicine”

This study demonstrated that a 3D air–liquid culture system using Wnt-CM-treated cells can induce hair regeneration in nude mice and may facilitate large-scale preparation for hair loss treatment.

research Modulating Hair Follicle Size with Wnt10b/DKK1 During Hair Regeneration

53 citations , April 2014 in “Experimental Dermatology”

In this study, ectopic Wnt10b-mediated β-catenin activation in hair follicles resulted in larger regenerating anagen hair structures, an effect modulated by the Wnt inhibitor DKK1.

Dermal Papilla Cells Serially Cultured with Wnt-10b Sustain Their Hair Follicle Induction Activity After Transplantation into Nude Mice

research Dermal Papilla Cells Serially Cultured with Wnt-10b Sustain Their Hair Follicle Induction Activity After Transplantation into Nude Mice

22 citations , October 2012 in “Cell Transplantation”

This study found that adding Wnt-10b to the culture medium of dermal papilla cells maintained their ability to induce hair follicles over 100 days in vitro.

research Comparative Secretome Analysis of Human Follicular Dermal Papilla Cells and Fibroblasts Using Shotgun Proteomics

44 citations , April 2012 in “BMB Reports”

This study identified several DPC-specific proteins, including ITGB1, IGFBP3, and THBS1, as potential biomarkers for hair growth modulation through proteomic and network analysis.

research Control of Hair Follicle Cell Fate by Underlying Mesenchyme Through a CSL–Wnt5a–FoxN1 Regulatory Axis

95 citations , July 2010 in “Genes & development”

In this study, the researchers reported that Notch/CSL signaling is crucial for hair follicle differentiation, with Wnt5a signaling and FoxN1 acting as mediators in mice.

research Review of Hair Follicle Dermal Cells

321 citations , December 2009 in “Journal of Dermatological Science”

This review discusses the role of dermal cells in hair follicle regeneration and morphogenesis and highlights their potential therapeutic implications, but it reports no new empirical findings.

research Hair Cycle-Specific Expression of Versican in Human Hair Follicles

88 citations , May 2005 in “Journal of Dermatological Science”

In this study, specific versican expression was observed in the anagen phase of human hair follicles, suggesting its importance in maintaining normal hair growth.

Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

research Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

208 citations , December 2003 in “Journal of Investigative Dermatology”

This study found that dermal papilla and peribulbar dermal sheath cup cells in mice can both induce hair follicle formation, suggesting they may have similar functional roles in hair growth.