Titrated Extract of Centella Asiatica Increases Hair Inductive Property Through Inhibition of STAT Signaling Pathway in Three-Dimensional Spheroid Cultured Human Dermal Papilla Cells

October 2017 in “ Bioscience, Biotechnology, and Biochemistry ”

Youngkeun Choi, Sungkwan An, Junwoo Lee, Jae Ho Lee, Jae Nam Lee, Young Sam Kim, Kyu Joong Ahn, In-Sook An, Seunghee Bae

Studysummary This study found that a titrated extract of Centella asiatica enhanced the hair growth potential of 3D spheroid cultured human dermal papilla cells. Our plain-language summary of this paper — not a Tressless recommendation.

The study from December 2, 2017, demonstrated that Titrated Extract of Centella asiatica (TECA) enhances hair growth properties by increasing cell viability and spheroid size in three-dimensional cultured human dermal papilla cells (HDP cells). TECA was shown to inhibit the STAT signaling pathway, evidenced by decreased activity of STAT reporter genes and reduced expression of STAT-targeted genes SOCS1 and SOCS3. It also upregulated hair growth-related genes and decreased levels of phosphorylated STAT proteins. These findings suggest TECA's potential as a treatment for hair loss by promoting hair inductivity in HDP cells. The study was conducted in vitro, and the number of cells used was not specified in the summary. Further research is needed to understand the exact mechanisms by which TECA affects hair induction. The research was funded by the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea.

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