Targeting JAK/STAT and Wnt/Beta-Catenin Pathways and 5-Alpha-Reductase Activity to Develop an Effective Anti-Hair Loss Product
December 2022
in “
Journal of Investigative Dermatology
”
JAK/STAT pathway Wnt/b-catenin pathway 5a-reductase Nasturtium officinale Tropaeolum majus Garcinia Mangostana Glyceryl laurate hair follicle dermal papilla cells outer root sheath keratinocytes testosterone DHT anagen hairs telogen hairs anagen/telogen ratio watercress Indian cress mangosteen Dihydrotestosterone
TLDR The lotion with specific plant extracts effectively increased hair growth and improved hair cycle in subjects after 3 months.
The study aimed to develop an effective anti-hair loss product by targeting the Wnt/b-catenin and JAK/STAT pathways, and 5a-reductase activity. The active ingredients were tested for their ability to regulate the hair cycle. The combination of Nasturtium officinale and Tropaeolum majus extracts increased the activation of Wnt/b-catenin by 38% in hair follicle dermal papilla cells. Garcinia Mangostana extract reduced JAK/STAT activation in outer root sheath keratinocytes by 33%. Glyceryl laurate reduced the conversion of testosterone to DHT by 42%, suggesting that 5a-reductase activity was inhibited. A lotion containing these ingredients was tested on 60 subjects for 3 months. The lotion significantly increased the number of anagen hairs and the anagen/telogen ratio, and decreased the number of telogen hairs after 3 months of treatment.
