Targeting JAK/STAT and Wnt/Beta-Catenin Pathways and 5-Alpha-Reductase Activity to Develop an Effective Anti-Hair Loss Product

    November 2022 in “ Journal of Investigative Dermatology ”
    Camille Mas, M. Froliger, Virginie Turlier, M. Lévêque, Séverine Carrère, S. Daunes Marion, Marie-José Haure, A. Noustens, H. Duplan, Sandrine Bessou Touya
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    TLDR The lotion with specific plant extracts effectively increased hair growth and improved hair cycle in subjects after 3 months.
    The study aimed to develop an effective anti-hair loss product by targeting the Wnt/b-catenin and JAK/STAT pathways, and 5a-reductase activity. The active ingredients were tested for their ability to regulate the hair cycle. The combination of Nasturtium officinale and Tropaeolum majus extracts increased the activation of Wnt/b-catenin by 38% in hair follicle dermal papilla cells. Garcinia Mangostana extract reduced JAK/STAT activation in outer root sheath keratinocytes by 33%. Glyceryl laurate reduced the conversion of testosterone to DHT by 42%, suggesting that 5a-reductase activity was inhibited. A lotion containing these ingredients was tested on 60 subjects for 3 months. The lotion significantly increased the number of anagen hairs and the anagen/telogen ratio, and decreased the number of telogen hairs after 3 months of treatment.
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