Search

for
Search:

Did you mean JAK-STAT pathway?

GlossaryJAK-STAT pathway

transmits signals from cell surface to nucleus for gene expression

The JAK-STAT pathway, short for Janus kinase-signal transducer and activator of transcription pathway, is a chain of interactions between proteins in a cell that transmits signals from chemical signals outside the cell to the cell nucleus, resulting in DNA transcription and activity changes. This pathway is crucial for regulating immune function, cell growth, and development, and has been implicated in various diseases, including certain types of alopecia and cancers.

Related Terms

Learn

0 / 0 results

— no results

Research

5 / 1000+ results

Titrated Extract of Centella Asiatica Increases Hair Inductive Property Through Inhibition of STAT Signaling Pathway in Three-Dimensional Spheroid Cultured Human Dermal Papilla Cells

research Titrated Extract of Centella Asiatica Increases Hair Inductive Property Through Inhibition of STAT Signaling Pathway in Three-Dimensional Spheroid Cultured Human Dermal Papilla Cells

13 citations , October 2017 in “Bioscience, Biotechnology, and Biochemistry”

Centella asiatica extract may help promote hair growth by blocking a specific cell signaling pathway.

research Mesenchymal Stem Cells Antagonize IFN-Induced Proinflammatory Changes and Growth Inhibition Effects via Wnt/β-Catenin and JAK/STAT Pathway in Human Outer Root Sheath Cells and Hair Follicles

14 citations , April 2021 in “International journal of molecular sciences”

Mesenchymal stem cells may help treat hair loss by improving hair cell growth and reducing inflammation.

research Scoping Review on the Use of Drugs Targeting JAK/STAT Pathway in Atopic Dermatitis, Vitiligo, and Alopecia Areata

55 citations , October 2019 in “Dermatology and therapy”

Drugs targeting the JAK/STAT pathway can improve atopic dermatitis but vary in effectiveness for vitiligo and alopecia areata, with generally mild safety concerns.

research An Overview of JAK/STAT Pathways and JAK Inhibition in Alopecia Areata

40 citations , August 2022 in “Frontiers in immunology”

Blocking JAK/STAT pathways can help treat hair loss from alopecia areata.

research Drugs Targeting the JAK/STAT Pathway for the Treatment of Immune-Mediated Inflammatory Skin Diseases: Protocol for a Scoping Review

17 citations , May 2019 in “BMJ Open”

JAK/STAT inhibitors show promise for skin diseases but aren't yet approved.

View more "stat pathway" in research →

Community Join

5 / 45 results

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

in Research/Science 210 upvotes 11 months ago

PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

community What else is good. Besides the big 3.

in Chat 35 upvotes 1 year ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

community Density loss after 4 months on DUTASTERIDE, does it get better if you stick with it?

in Finasteride/Dutasteride 3 upvotes 1 year ago

A user experienced increased hair density loss after 4 months on dutasteride combined with finasteride. They are also using topical dutasteride with azelaic acid and alfatradiol but cannot tolerate antiandrogens like RU58841 due to headaches.

community How I recovered from 4+ years of severe balding ages 20-24 by dieting, lifestyle changes and ONLY using topical minoxidil

in Progress Pictures 473 upvotes 3 months ago

A user reversed severe hair loss with dieting, lifestyle changes, and topical minoxidil, highlighting reduced inflammation and body fat. The conversation debates finasteride's effectiveness and the impact of diet and lifestyle on hair health.

View more "stat pathway" in community →