Mesenchymal Stem Cells Antagonize IFN-Induced Proinflammatory Changes and Growth Inhibition Effects via Wnt/β-Catenin and JAK/STAT Pathway in Human Outer Root Sheath Cells and Hair Follicles
April 2021
in “
International journal of molecular sciences
”
mesenchymal stem cells human hematopoietic mesenchymal stem cells hHMSCs human outer root sheath cells hORSCs alopecia areata AA interferon-gamma IFN-γ mesenchymal stem cell therapy MSCT Wnt/β-catenin signaling pathway JAK/STAT pathway hair stem cell markers anagen survival stem cells hair follicle cells hair loss immune response stem cell therapy hair growth pathway inflammation pathway hair growth markers hair growth phase
Studysummary This study found that human hematopoietic mesenchymal stem cells increased the viability and migration of human outer root sheath cells in an in vitro alopecia areata model, involving Wnt/β-catenin and JAK/STAT pathways.
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