Mesenchymal Stem Cells Antagonize IFN-Induced Proinflammatory Changes and Growth Inhibition Effects via Wnt/β-Catenin and JAK/STAT Pathway in Human Outer Root Sheath Cells and Hair Follicles

    Yujin Lee, Song-Hee Park, Hye-Ree Park, Young Lee, Hoon Kang, Jung Eun Kim
    TLDR Mesenchymal stem cells may help treat hair loss by improving hair cell growth and reducing inflammation.
    The study demonstrated that mesenchymal stem cell therapy (MSCT) could counteract interferon-gamma (IFN-γ)-induced proinflammatory changes and growth inhibition in human outer root sheath cells (hORSCs) and hair follicles (HFs) by modulating the Wnt/β-catenin and JAK/STAT pathways. MSCT increased hair growth factors, improved cell viability and migration, and promoted hair growth in an ex vivo mouse model. These findings suggested that MSCT could be a promising therapeutic approach for conditions like alopecia areata (AA) by promoting hair growth and reducing inflammation.
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