Mesenchymal Stem Cells Antagonize IFN-Induced Proinflammatory Changes and Growth Inhibition Effects via Wnt/β-Catenin and JAK/STAT Pathway in Human Outer Root Sheath Cells and Hair Follicles

April 2021 in “ International journal of molecular sciences ”

Yujin Lee, Song-Hee Park, Hye-Ree Park, Young Lee, Hoon Kang, Jung Eun Kim

TLDR Mesenchymal stem cells may help treat hair loss by improving hair cell growth and reducing inflammation.

The study demonstrated that mesenchymal stem cell therapy (MSCT) could counteract interferon-gamma (IFN-γ)-induced proinflammatory changes and growth inhibition in human outer root sheath cells (hORSCs) and hair follicles (HFs) by modulating the Wnt/β-catenin and JAK/STAT pathways. MSCT increased hair growth factors, improved cell viability and migration, and promoted hair growth in an ex vivo mouse model. These findings suggested that MSCT could be a promising therapeutic approach for conditions like alopecia areata (AA) by promoting hair growth and reducing inflammation.

View this study on mdpi.com →

Discuss this study in the Community →

Cited in this study

22 / 22 results

research The Effect of JAK Inhibitor on Survival, Anagen Re-Entry, and Hair Follicle Immune Privilege Restoration in Human Dermal Papilla Cells

16 citations , July 2020 in “International Journal of Molecular Sciences”

Ruxolitinib may help treat hair loss by reducing inflammation, promoting hair growth signals, and protecting hair follicle immunity.

research Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

86 citations , July 2020 in “International Journal of Molecular Sciences”

Activating the Wnt/β-catenin pathway could lead to new hair loss treatments.

research Overexpression of Nanog in Amniotic Fluid-Derived Mesenchymal Stem Cells Accelerates Dermal Papilla Cell Activity and Promotes Hair Follicle Regeneration

14 citations , July 2019 in “Experimental and Molecular Medicine”

Nanog gene boosts stem cells, helps hair growth, and may treat hair loss.

research Treatment of Telogen Effluvium Using a Dietary Supplement Containing Boswellia Serrata, Curcuma Longa, and Vitis Vinifera: Results of an Observational Study

37 citations , February 2019 in “Dermatologic Therapy”

A dietary supplement with Boswellia serrata, Curcuma longa, and Vitis vinifera showed potential improvement in hair health for telogen effluvium patients, but more research is needed.

research Synthesized Ceramide Induces Growth of Dermal Papilla Cells with Potential Contribution to Hair Growth

7 citations , January 2019 in “Annals of dermatology/Annals of Dermatology”

Synthetic ceramides may help hair growth by boosting cell growth in hair follicles.

research Effects of Mesenchymal Stem Cell Therapy on Alopecia Areata in Cellular and Hair Follicle Organ Culture Models

16 citations , December 2018 in “Experimental Dermatology”

Mesenchymal stem cell therapy may help treat alopecia areata by promoting hair growth and reducing inflammation.

research Stem Cell Therapy as a Novel Therapeutic Intervention for Resistant Cases of Alopecia Areata and Androgenetic Alopecia

39 citations , March 2018 in “Journal of Dermatological Treatment”

Stem cell therapy may help treat tough hair loss cases.

research Wnt/β-Catenin and ERK Pathway Activation: A Possible Mechanism of Photobiomodulation Therapy with Light-Emitting Diodes That Regulate the Proliferation of Human Outer Root Sheath Cells

43 citations , September 2017 in “Lasers in Surgery and Medicine”

LED light therapy may help hair growth by activating certain cell pathways.

research Double-Stranded RNA Induces Inflammation via the NF-κB Pathway and Inflammasome Activation in the Outer Root Sheath Cells of Hair Follicles

22 citations , March 2017 in “Scientific reports”

Double-stranded RNA causes inflammation in hair follicle cells, which may help understand and treat alopecia areata.

research Induction of Hair Follicle Dermal Papilla Cell Properties in Human Induced Pluripotent Stem Cell-Derived Multipotent LNGFR(+)THY-1(+) Mesenchymal Cells

42 citations , February 2017 in “Scientific Reports”

Researchers found a way to create cells from stem cells that act like human cells important for hair growth and could be used for hair regeneration treatments.

research STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction

32 citations , September 2016 in “Journal of Investigative Dermatology”

STAT5 activation is crucial for starting the hair growth phase.

research Epidermal Growth Factor Promotes Proliferation and Migration of Follicular Outer Root Sheath Cells via Wnt/β-Catenin Signaling

43 citations , January 2016 in “Cellular physiology and biochemistry”

Epidermal Growth Factor helps hair follicle cells grow and move by activating a specific cell signaling pathway.

research Hair Growth-Promotion Effects of Different Alternating Current Parameter Settings Are Mediated by the Activation of Wnt/β-Catenin and MAPK Pathway

27 citations , October 2015 in “Experimental Dermatology”

Certain electric currents can promote hair growth by activating specific cell pathways.

research Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth

159 citations , October 2015 in “Science Advances”

Blocking JAK-STAT signaling can lead to hair growth.

research Biology of the Hair Follicle and Mechanisms of Nonscarring and Scarring Alopecia

10 citations , June 2015 in “Seminars in cutaneous medicine and surgery”

Hair loss can be caused by various factors, and treatments focus on restoring normal hair growth.

research Hair Regrowth in Alopecia Areata Patients Following Stem Cell Educator Therapy

55 citations , April 2015 in “BMC medicine”

Stem Cell Educator therapy helps regrow hair and improve life quality in alopecia areata patients.

research Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type

184 citations , December 2014 in “Developmental Cell”

Hair follicle dermal stem cells are key for regenerating parts of the hair follicle and determining hair type.

research Keratin K15 as a Biomarker of Epidermal Stem Cells

85 citations , September 2013 in “International Journal of Molecular Sciences”

Keratin 15 is not a reliable sole marker for identifying epidermal stem cells because it's found in various cell types.