Restoration of Follicular β-Catenin Signaling by Mesenchymal Stem Cells Promotes Hair Growth in Mice with Androgenetic Alopecia

    November 2024 in “ Stem Cell Research & Therapy
    Wenjing Yan, Jiakun Liu, Xuedong Xie, Qianqian Jin, Yue Yang, Yi Pan, Yanfeng Zhang, Fangfang Zhang, Yan Wang, Jianxing Liu, 良樹 鷹津
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    TLDR Stem cells from umbilical cords can help regrow hair in mice with hair loss.
    The study demonstrates that human umbilical cord mesenchymal stem cells (hUCMSCs) can promote hair growth in mice with androgenetic alopecia (AGA) by activating the Wnt/β-catenin signaling pathway. This activation reduces apoptosis in dermal papilla cells (DPCs) and enhances the proliferation of hair follicle stem cells (HFSCs), leading to increased hair follicle density and skin thickness. The research involved 30 mice and suggests that hUCMSCs could offer a promising alternative to current AGA treatments by improving the hair follicle growth environment and signaling.
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