Restoration of Follicular β-Catenin Signaling by Mesenchymal Stem Cells Promotes Hair Growth in Mice with Androgenetic Alopecia

    November 2024 in “ Stem Cell Research & Therapy
    Wenjing Yan, Jiakun Liu, Xuedong Xie, Qianqian Jin, Yue Yang, Yi Pan, Yanfeng Zhang, Fangfang Zhang, Yan Wang, Jianxing Liu, 良樹 鷹津
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    The study investigates the effects of human umbilical cord mesenchymal stem cells (hUCMSCs) on hair growth in androgenetic alopecia (AGA) model mice. Intradermal transplantation of hUCMSCs in these mice resulted in increased hair growth, hair follicle density, skin thickness, and activation of the anagen phase, while reducing apoptosis in dermal papilla cells (DPCs) and promoting hair follicle stem cell (HFSC) proliferation. The mechanism involves the activation of the Wnt/β-catenin signaling pathway in DPCs, which is crucial for hair regeneration. Blocking β-catenin degradation led to increased DPC apoptosis and reduced HFSC proliferation, highlighting the importance of this pathway in the therapeutic effects of hUCMSCs on AGA.
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