Regenerative Medicine in the Treatment of Specific Dermatologic Disorders: A Systematic Review of Randomized Controlled Clinical Trials

June 2024 in “ Stem cell research & therapy ”

Alireza Jafarzadeh, Arash Pour Mohammad, Haniyeh Keramati, Roya Zeinali, Mina Khosravi, Azadeh Goodarzi

androgenetic alopecia vitiligo platelet-rich plasma autologous epidermal melanocyte/keratinocyte cell transplantation hair density hair count repigmentation AGA PRP

TLDR Regenerative medicine shows promise for treating skin disorders like hair loss and vitiligo.

This systematic review analyzed 64 randomized controlled trials involving 2,888 patients to evaluate the effectiveness of regenerative medicine in treating various dermatologic disorders, particularly androgenetic alopecia (AGA) and vitiligo. The study found high effectiveness rates for regenerative treatments, with PRP being the most frequently used method, showing significant improvements in hair density and count for AGA and repigmentation for vitiligo. Other methods like autologous epidermal melanocyte/keratinocyte cell transplantation also demonstrated significant effectiveness. The review underscores the promising role of regenerative medicine in dermatology but calls for further clinical trials to validate these results.

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research Efficacy of Topical Minoxidil and Oral Spironolactone Versus Minoxidil and Finasteride in Androgenic Alopecia

August 2023 in “Journal of Cosmetic Dermatology”

Both minoxidil-spironolactone and minoxidil-finasteride treatments work for hair loss, but minoxidil-spironolactone is slightly more effective, especially in women.

research Combination of Adipose-Derived Stem Cell Conditioned Media and Minoxidil for Hair Regrowth in Male Androgenetic Alopecia: A Randomized, Double-Blind Clinical Trial

August 2023 in “Stem Cell Research & Therapy”

Using adipose-derived stem cell media with minoxidil may help regrow hair in men with hair loss.

research Evaluation of Platelet-Rich Plasma Plus Basic Fibroblast Growth Factor Combined With Minoxidil in the Treatment of Androgenetic Alopecia: A Randomized Controlled Trial

May 2023 in “Journal of Cosmetic Dermatology”

Using platelet-rich plasma, basic fibroblast growth factor, and minoxidil together significantly increases hair count and growth rate in people with hair loss.

research Efficacy of Autologous Platelet-Rich Plasma Therapy Versus Topical Minoxidil in Men With Moderate Androgenetic Alopecia: A Randomized Open-Label Trial

February 2023 in “Journal of Dermatological Treatment”

research Effect of Platelet Counts and Activator in Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia, Split-Head Comparison: A Randomised, Double-Blind Study

January 2023 in “Indian Journal of Dermatology, Venereology and Leprology”

research Comparative Study Between Intralesional Injection of Platelet Rich Plasma and Triamcinolone for the Treatment of Alopecia Areata

September 2022 in “Journal of Ayub Medical College Abbottabad”

Steroid injections are more effective than platelet rich plasma for treating patchy hair loss.

research Efficacy of Platelet-Rich Plasma in Asians With Androgenetic Alopecia: A Randomized Controlled Trial

September 2022 in “Indian Journal of Dermatology, Venereology and Leprology”

research Evaluation of the Safety and Efficacy of Platelet-Rich Plasma in the Treatment of Female Patients with Chronic Telogen Effluvium: A Randomized, Controlled, Double-Blind, Pilot Clinical Trial

2 citations , April 2022 in “Indian Journal of Dermatology, Venereology and Leprology”

Platelet-rich plasma is a promising and safe treatment for increasing hair density and thickness in women with chronic telogen effluvium.

research Clinical Evaluation of Intradermal Platelet-Rich Plasma Administration Along with Oral Biotin Supplement for the Management of Androgenetic Alopecia in Adult Males: A Randomized Clinical Trial

January 2022 in “Journal of Clinical and Diagnostic Research”

Using platelet-rich plasma injections and biotin pills together significantly increases hair regrowth in men with hair loss.

research Platelet Rich Plasma Application by Dermapen Microneedling and Intradermal Point-by-Point Injection Methods, and Their Comparison with Clinical Findings and Trichoscan in Patients with Androgenetic Alopecia

3 citations , October 2021 in “Dermatologic Therapy”

research Randomized Control Trial to Study the Efficacy and Safety of Platelet-Rich Plasma as Intraoperative Holding Solution in Hair Restoration Surgery: A Pilot Study

July 2021 in “Medical journal, Armed Forces India”

Using platelet-rich plasma in hair restoration surgery significantly improves hair density after 6 months and is safe to use.

research Autologous Concentrated Growth Factors Combined With Topical Minoxidil for the Treatment of Male Androgenetic Alopecia: A Randomized Controlled Clinical Trial

4 citations , July 2021 in “Facial plastic surgery & aesthetic medicine”

Combining growth factors with minoxidil improves hair growth more than minoxidil alone.

research The Effects of Lower vs Higher Cell Number of Platelet-Rich Plasma on Hair Density and Diameter in Androgenetic Alopecia: A Randomized, Double-Blinded, Placebo, Parallel-Group Half-Scalp IRB-Approved Study

6 citations , May 2021 in “Aesthetic Surgery Journal”

research Comparison of Efficacy of Topical 5% Minoxidil Alone Versus Topical 5% Minoxidil With Autologous Platelet-Rich Plasma (PRP) Therapy in Treatment of Androgenetic Alopecia: A Randomized Open Label Study

May 2021 in “IP Indian journal of clinical and experimental dermatology”

research Evaluation of Platelet-Rich Plasma on Hair Regrowth and Lesional T-Cell Cytokine Expression in Alopecia Areata: A Randomized Observer-Blinded, Placebo-Controlled, Split-Head Pilot Study

9 citations , May 2021 in “Journal of The American Academy of Dermatology”

Platelet-rich plasma may help restore immune balance in bald patches, but its effectiveness in treating hair loss is limited.

research Evaluation of Adding Platelet-Rich Plasma to Combined Medical Therapy in Androgenetic Alopecia

5 citations , January 2021 in “Journal of Cosmetic Dermatology”

Adding platelet-rich plasma improves hair density and thickness in androgenetic alopecia.

research The Effect of Conditioned Media From Human Adipocyte-Derived Mesenchymal Stem Cells on Androgenetic Alopecia After Nonablative Fractional Laser Treatment

10 citations , December 2020 in “Dermatologic Surgery”

research The Effect of Platelet-Rich Plasma on Female Androgenetic Alopecia: A Randomized Controlled Trial

18 citations , November 2020 in “Journal of The American Academy of Dermatology”

PRP injections improve hair density and thickness in women with hair loss.

research Evaluation of Platelet-Rich Plasma as a Treatment for Androgenetic Alopecia: A Randomized Controlled Trial

33 citations , November 2020 in “Journal of The American Academy of Dermatology”

PRP treatment improves hair density and thickness for alopecia, but needs more research.

research A Randomized, Double-Blind, Vehicle-Controlled Clinical Study of Hair Regeneration Using Adipose-Derived Stem Cell Constituent Extract in Androgenetic Alopecia

25 citations , August 2020 in “Stem Cells Translational Medicine”

ADSC-CE treatment safely increases hair density and thickness in androgenetic alopecia patients.

research Platelet-Rich Plasma for Androgenetic Alopecia Treatment: A Randomized Placebo-Controlled Pilot Study

8 citations , July 2020 in “Acta dermato-venereologica”

research A Randomized, Controlled Pilot Trial Comparing Platelet-Rich Plasma to Topical Minoxidil Foam for Treatment of Androgenic Alopecia in Women

22 citations , June 2020 in “Dermatologic Surgery”

Both Platelet-Rich Plasma and Minoxidil foam increase hair count in women with hair loss, but Minoxidil is more effective. However, women were more satisfied with Platelet-Rich Plasma treatment.

research Platelet-Rich Plasma Injections in the Treatment of Male Androgenetic Alopecia: A Randomized Placebo-Controlled Crossover Study

9 citations , May 2020 in “Journal of Cosmetic Dermatology”

PRP injections improve hair density in male hair loss.

research Growth Factor Concentrations in Platelet-Rich Plasma for Androgenetic Alopecia: An Intra-Subject, Randomized, Blinded, Placebo-Controlled, Pilot Study

13 citations , March 2020 in “Experimental Dermatology”

PRP growth factor concentrations vary, no significant hair growth difference found.

research Comparison of Efficacy of Platelet-Rich Plasma Therapy With or Without Topical 5% Minoxidil in Male-Type Baldness: A Randomized, Double-Blind Placebo Control Trial

26 citations , January 2020 in “Indian Journal of Dermatology, Venereology and Leprology”

research A Randomized Pilot Study to Compare Hair Follicle Cell Suspensions Prepared Using Trypsin Alone Versus Trypsin in Combination with Collagenase Type I for Transplantation in Vitiligo

5 citations , September 2019 in “Clinical and experimental dermatology”

Adding collagenase to trypsin improves cell yield and repigmentation in vitiligo treatment.

research Treatment of Male Pattern Alopecia with Platelet-Rich Plasma: A Double-Blind Controlled Study with Analysis of Platelet Number and Growth Factor Levels

57 citations , March 2019 in “Journal of The American Academy of Dermatology”

Platelet-rich plasma treatment can significantly increase hair count and density in men with pattern baldness, and these improvements can last up to 3 months.

research Evaluating the Efficacy of Different Platelet-Rich Plasma Regimens for Management of Androgenetic Alopecia: A Single-Center, Blinded, Randomized Clinical Trial

46 citations , September 2018 in “Dermatologic Surgery”

PRP injections effectively treat hair loss, with positive results in both monthly and every three months treatments.

research The Effect of Autologous Activated Platelet-Rich Plasma Injection on Female Pattern Hair Loss: A Randomized Placebo-Controlled Study

52 citations , February 2018 in “Journal of Cosmetic Dermatology”

PRP injections improve hair density and thickness in women with hair loss.

research Platelet-Rich Plasma Versus Minoxidil 5% in Treatment of Alopecia Areata: A Trichoscopic Evaluation

62 citations , January 2017 in “Dermatologic Therapy”

PRP more effective than minoxidil 5% for treating alopecia areata.

research Double-Blind, Placebo-Controlled Pilot Study on the Use of Platelet-Rich Plasma in Women With Female Androgenetic Alopecia

87 citations , November 2016 in “Dermatologic Surgery”

PRP shows potential for treating female hair loss, but more research needed.

research Efficacy of Platelet-Rich Plasma in the Treatment of Androgenetic (Male-Patterned) Alopecia: A Pilot Randomized Controlled Trial

61 citations , October 2016 in “Journal of Cosmetic and Laser Therapy”

Platelet-rich plasma (PRP) was found not effective in treating male-patterned hair loss.

research Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia

136 citations , April 2016 in “Dermatologic Surgery”

PRP treatment helps hair growth and density in androgenetic alopecia patients.

research The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial

214 citations , September 2015 in “Stem Cells Translational Medicine”

Platelet-rich plasma injections significantly improved hair regrowth and thickness in patients with hair loss.

research A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata

205 citations , August 2013 in “British Journal of Dermatology”

Platelet-rich plasma treatment significantly increased hair regrowth and decreased discomfort in alopecia patients, making it a potentially better and safer treatment option.