Regenerative Medicine in the Treatment of Specific Dermatologic Disorders: A Systematic Review of Randomized Controlled Clinical Trials

This study found that combining minoxidil and spironolactone was more effective for hair density and severity of hair loss in women with androgenic alopecia compared to minoxidil and finasteride, with no serious adverse effects reported.

In this study on male androgenetic alopecia, the researchers reported significant increases in hair count, density, and thickness with minimal side effects over 6 weeks using adipose-derived stem cell conditioned media and minoxidil, but found no significant differences between concentrated and non-concentrated treatments.

This prospective randomized controlled trial found that combining platelet-rich plasma plus basic fibroblast growth factor injections with topical minoxidil significantly improves hair count and growth rate in androgenetic alopecia patients compared to either treatment alone.

In this study, both platelet-rich plasma and minoxidil increased hair counts and density in moderate androgenetic alopecia in men, but patient satisfaction was higher with minoxidil, which also had fewer side effects.

In this study, activated platelet-rich plasma improved hair density and thickness in patients with androgenetic alopecia, with higher platelet counts enhancing these effects over time.

This randomized controlled trial found that intralesional injections of triamcinolone were significantly more effective than platelet rich plasma for treating alopecia areata on the scalp, although platelet rich plasma was considered a viable alternative due to its lack of serious side effects.

This pilot study suggests that platelet-rich plasma may be a promising treatment for chronic telogen effluvium with good safety, and cost-effective preparation methods may be reliable alternatives to more expensive ones.

This study found that intradermal administration of PRP combined with oral biotin significantly increased hair regrowth in men with androgenetic alopecia, without notable side effects.

This study demonstrated that PRP treatment improved hair metrics in androgenetic alopecia, with the dermapen method proving more effective than the point-by-point technique for specific hair growth indicators.

This study reported that using platelet-rich plasma as an intraoperative holding solution significantly improved hair density and follicular growth in hair restoration surgery for androgenetic alopecia.

This study found that intradermal injections of platelet-rich plasma were equally safe and effective for treating androgenetic alopecia, with higher platelet numbers possibly enhancing hair density and follicle diameter.

This study found that combining topical 5% minoxidil with autologous PRP therapy significantly increased hair density in men with androgenetic alopecia compared to minoxidil alone, without major side effects.

This study found that adding platelet-rich plasma with microneedling to conventional medical treatment significantly increased hair density and diameter in androgenetic alopecia patients compared to medical treatment alone.

This study found that platelet-rich plasma had limited efficacy in treating alopecia areata but may help restore immune balance in the affected areas.

This study found that combining concentrated growth factor injections with minoxidil treatment significantly improved hair growth and participant satisfaction in male patients with androgenetic alopecia compared to minoxidil alone.

In this study, human ADSC-CM treatment following nonablative fractional laser significantly increased hair density and volume in patients with androgenetic alopecia without any reported adverse effects.

In this study, PRP increased hair density in areas treated for androgenetic alopecia, but there was no significant difference when compared to placebo-treated areas.

This study found that PRP injections using the Eclipse system significantly improved hair density and caliber in women with androgenetic alopecia compared to saline placebo at 24 weeks.

In this randomized clinical trial, the authors reported that adipose-derived stem cell constituent extract topical solution increased hair density and thickness in patients with androgenetic alopecia over 16 weeks compared to placebo.

This pilot clinical trial suggests that platelet-rich plasma (PRP) treatment may increase hair density in patients with androgenetic alopecia, though outcomes varied between patients.

This pilot study found that platelet-rich plasma injections did not improve hair growth in men with androgenetic alopecia.

This study found that platelet-rich plasma combined with topical minoxidil was more effective in increasing hair density for male-type baldness than either treatment alone.

This study found that platelet-rich plasma was effective for hair regrowth in women with androgenic alopecia, though less so than minoxidil, but it was associated with improved quality of life responses.

This study found that platelet-rich plasma injections significantly increased hair density in men with androgenetic alopecia compared to placebo, but further research is needed to understand factors influencing treatment success.

This study found that incorporating collagenase type I into a noncultured hair follicle cell suspension technique improved cell yield and enhanced repigmentation in patients with stable vitiligo compared to dermabrasion alone.

This study found that platelet-rich plasma significantly increased hair count, density, and the percentage of anagen hairs in patients with androgenetic alopecia, but these improvements did not correlate with platelet or growth factor levels.

In this study, subdermal platelet-rich plasma injections significantly increased hair count and shaft caliber in individuals with androgenetic alopecia, with monthly treatments potentially offering greater benefits.

This study found that platelet-rich plasma injections significantly improved hair density, thickness, and patient satisfaction in women with female pattern hair loss compared to a placebo.

This study found that platelet-rich plasma was more effective for treating alopecia areata than topical 5% minoxidil, leading to earlier hair regrowth and reduction in hair abnormalities.

This study found that platelet-rich plasma did not significantly improve hair mass index or hair count in women with female androgenetic alopecia, though some patients perceived benefits in hair quality.

This study found that platelet-rich plasma was not effective in treating androgenetic alopecia in men with grade 4–6 hair loss.

This study found that platelet-rich plasma significantly increased hair density and anagen hair proportions in androgenetic alopecia patients, suggesting potential as an adjuvant therapy.

This study found that platelet-rich plasma injections significantly increased hair count and density in patients with male pattern hair loss without major side effects, suggesting it may be a safe and effective treatment option.

In this study, platelet-rich plasma significantly increased hair regrowth and reduced symptoms of alopecia areata compared to triamcinolone acetonide or placebo, with no observed side effects.