Combination of Adipose-Derived Stem Cell Conditioned Media and Minoxidil for Hair Regrowth in Male Androgenetic Alopecia: A Randomized, Double-Blind Clinical Trial

    August 2023 in “ Stem Cell Research & Therapy ”
    Lili Legiawati, Lis Surachmiati Suseno, Irma Bernadette S. Sitohang … Kanya Ayu Paramastri
    Studysummary In this study on male androgenetic alopecia, the researchers reported significant increases in hair count, density, and thickness with minimal side effects over 6 weeks using adipose-derived stem cell conditioned media and minoxidil, but found no significant differences between concentrated and non-concentrated treatments.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on stemcellres.biomedcentral.com →
    Discuss this study in the Community →

    Research cited in this study 25

    1. Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics Journal of Cosmetic Dermatology · 2021
    2. Microneedling for Hair Loss Journal of Cosmetic Dermatology · 2021
    3. Health-Related Quality of Life, Depression, and Self-Esteem in Patients With Androgenetic Alopecia JAMA Dermatology · 2021
    4. Clinical Efficacy of Adipocyte-Derived Stem Cells Conditioned Media Combined with Micro-Injury in Refractory Patch of Alopecia Areata Archives of Dermatological Research · 2021
    5. Promotion of Hair Growth by Conditioned Medium from Extracellular Matrix/Stromal Vascular Fraction Gel in C57BL/6 Mice Stem Cells International · 2020
    6. A Randomized, Double-Blind, Vehicle-Controlled Clinical Study of Hair Regeneration Using Adipose-Derived Stem Cell Constituent Extract in Androgenetic Alopecia Stem Cells Translational Medicine · 2020
    7. Early-Onset Androgenetic Alopecia in China: A Descriptive Study of a Large Outpatient Cohort Journal of International Medical Research · 2020
    8. A Review of the Treatment of Male Pattern Hair Loss Expert Opinion on Pharmacotherapy · 2020
    9. Autologous Micrografts from Scalp Tissue: Trichoscopic and Long-Term Clinical Evaluation in Male and Female Androgenetic Alopecia BioMed Research International · 2020
    10. Sequential Scalp Assessment in Hair Regeneration Therapy Using an Adipose-Derived Stem Cell-Conditioned Medium Dermatologic Surgery · 2019
    11. Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Regrowth in Androgenetic Alopecia: Biomolecular Pathway Analysis and Clinical Evaluation Biomedicines · 2019
    12. Comparative Study Between Mesotherapy and Topical 5% Minoxidil by Dermoscopic Evaluation for Androgenic Alopecia in Males: A Randomized Controlled Trial International Journal of Trichology · 2019
    13. Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia Journal of Visualized Experiments · 2018
    14. A Randomized Controlled, Single-Observer Blinded Study to Determine the Efficacy of Topical Minoxidil Plus Microneedling Versus Topical Minoxidil Alone in the Treatment of Androgenetic Alopecia Journal of Cutaneous and Aesthetic Surgery · 2018
    15. The Basic Mechanism of Hair Growth Stimulation by Adipose-Derived Stem Cells and Their Secretory Factors Current Stem Cell Research & Therapy · 2017
    16. Human Mesenchymal Stem Cell-Derived Conditioned Media for Hair Regeneration Applications PubMed · 2017
    17. Frequency, Severity, and Related Factors of Androgenetic Alopecia in Dermatology Outpatient Clinic: Hospital-Based Cross-Sectional Study in Turkey Anais Brasileiros De Dermatologia · 2017
    18. The Use of Adipose-Derived Stem Cells in Selected Skin Diseases (Vitiligo, Alopecia, and Nonhealing Wounds) Stem Cells International · 2017
    19. Lipid Profile in Patients with Androgenetic Alopecia: A Meta-Analysis Journal of The European Academy of Dermatology and Venereology · 2016
    20. Multi-Therapies in Androgenetic Alopecia: Review and Clinical Experiences Dermatologic Therapy · 2016
    21. The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial Stem Cells Translational Medicine · 2015
    22. Clinical Use of Conditioned Media of Adipose Tissue-Derived Stem Cells in Female Pattern Hair Loss: A Retrospective Case Series Study International Journal of Dermatology · 2015
    23. Androgenetic Alopecia: An Evidence-Based Treatment Update American Journal of Clinical Dermatology · 2014
    24. A Comparative Study of Dyslipidemia in Men and Women with Androgenic Alopecia Acta dermato-venereologica · 2010
    25. Male Androgenetic Alopecia: Population-Based Study in 1,005 Subjects International Journal of Trichology · 2009

    Related research 8

    1. Baricitinib Results in Eyebrow and Eyelash Growth in Patients With Alopecia Areata Who Do Not Achieve 20% or Less Scalp Hair Loss Journal of The American Academy of Dermatology · 2022
    2. Sisaipho Alopecia Areata Treated With Tofacitinib and Oral Minoxidil JAAD case reports · 2022
    3. Hair Loss (Alopecia or Baldness) 2018
    4. Treatments of Hereditary Hair Loss (Alopecia) 2018
    5. Characteristics of Korean Scalp Hair and Male Pattern Baldness Journal of The Korean Medical Association · 2013
    6. Effect of Minoxidil on Hair Growth in Androgenic Alopecia in Women PubMed · 2002
    7. Australian Trial of Topical Minoxidil and Placebo in Early Male Pattern Baldness Australasian Journal of Dermatology · 1990
    8. 2% Topical Minoxidil Solution in Male-Pattern Baldness: Preliminary European Results Dermatology · 1987