Health-Related Quality of Life, Depression, and Self-Esteem in Patients With Androgenetic Alopecia

    July 2021 in “ JAMA Dermatology
    Chun-Hsien Huang, Yun Fu, C. Y. Chi
    TLDR Androgenetic alopecia negatively affects quality of life and self-esteem, especially in women, but not depression.
    This systematic review and meta-analysis of 7995 patients across 41 studies found that androgenetic alopecia (AGA) was significantly associated with moderate impairment in health-related quality of life (HRQOL) and emotional well-being, as indicated by a Dermatology Life Quality Index score of 8.16 and a Hair-Specific Skindex-29 score of 29.22 in the emotion dimension. However, there was no significant association with depressive symptoms, with a Center for Epidemiologic Studies Depression Scale score of 14.98. Self-esteem was notably lower in women with female-pattern hair loss compared to men with AGA. Factors such as marital status and medical treatment were positively associated with HRQOL, while higher self-rated hair loss severity and higher educational level were inversely associated. The study suggested that patients with AGA might benefit from psychological and psychosocial support, despite limitations like the cross-sectional design of most studies and varied HRQOL assessment tools.
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