Clinical Efficacy of Adipocyte-Derived Stem Cells Conditioned Media Combined with Micro-Injury in Refractory Patch of Alopecia Areata

June 2021 in “ Archives of Dermatological Research ”

Seon Bok Lee, Hyun‐Tae Shin, Ji Won Byun, Jeonghyun Shin, Gwang Seong Choi

adipocyte-derived stem cell conditioned media ASC-CM carbon dioxide fractional laser microneedling alopecia areata stem cell conditioned media fractional laser AA

From the encyclopedia

Microneedling →

technique to create small wounds in skin to activate collagen production and hair growth

Alopecia Areata →

autoimmune disorder causing patchy hair loss

Studysummary In this study, researchers evaluated the use of adipocyte-derived stem cell conditioned media combined with fractional laser or microneedling for treating refractory alopecia areata, finding that 64.3% of patients had significant hair regrowth, suggesting this combination may be an effective and safe treatment option. Our plain-language summary of this paper — not a Tressless recommendation.

This study evaluated the clinical efficacy and safety of adipocyte-derived stem cell conditioned media (ASC-CM) combined with either a 10,600 nm carbon dioxide fractional laser or microneedling for treating refractory patches of alopecia areata (AA). Conducted retrospectively, it involved 14 patients treated between March 2017 and August 2020. Results showed that 9 out of 14 patients (64.3%) experienced more than 50% hair regrowth, with 6 patients (42.9%) achieving complete recovery. The average time to achieve over 50% hair regrowth in responders was 11.3 weeks. In contrast, 5 patients were non-responders, with 4 showing less than 25% regrowth and 1 showing slight regrowth after 3 months. The study concluded that ASC-CM combined with fractional laser or microneedling could be an effective and safe treatment option for refractory AA patches.

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Research cited in this study

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