Transepidermal Drug Delivery: A New Treatment Option for Areata Alopecia?

Transepidermal drug delivery (TED) using ablative fractional resurfacing and acoustic pressure ultrasound (US) to deliver triamcinolone showed promising results in treating areata alopecia (AA). In a study involving five AA patients, all experienced complete recovery of the treated areas. The treatment involved three steps: ablative fractioned RF or CO2 laser, topical triamcinolone application, and acoustic pressure wave US. The number of sessions required varied, with some patients achieving complete response after just one session, while others needed up to six sessions. This method demonstrated good clinical outcomes and a low incidence of side effects, suggesting it as a viable new treatment option for AA.