The Basic Mechanism of Hair Growth Stimulation by Adipose-Derived Stem Cells and Their Secretory Factors

September 2017 in “ Current Stem Cell Research & Therapy ”

Chong Hyun Won, Gyeong‐Hun Park, Xunwei Wu, Thanh-Nga Tran, Ki-young Park, Byung-Soon Park, Dong Young Kim, Oh Sang Kwon, Kyu-Han Kim

adipose-derived stem cells ADSCs secretory factors conditioned media ADSC-CM human follicular cells dermal papilla cells anagen phase hair shaft elongation mesenchymal stem cells stem cells hair growth stimulation hair loss treatment

TLDR Adipose-derived stem cells can help treat hair loss.

Adipose-derived stem cells (ADSCs) and their secretory factors were found to stimulate hair growth in various settings, including in vitro, ex vivo, and in vivo. The conditioned media of ADSCs (ADSC-CM) increased the proliferation rate of human follicular cells and improved hair growth by protecting human dermal papilla cells from cytotoxic injury. Additionally, ADSC-CM induced the anagen phase and promoted hair growth in mice, as well as enhanced hair shaft elongation in ex vivo human hair organ cultures. These findings suggested that ADSC-derived proteins could serve as feasible clinical therapeutic agents for treating hair loss, given the accessibility of ADSCs as a source of mesenchymal stem cells.

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