The Basic Mechanism of Hair Growth Stimulation by Adipose-Derived Stem Cells and Their Secretory Factors
September 2017
in “
Current Stem Cell Research & Therapy
”
Studysummary This review examines the effects of adipose-derived stem cells and their secreted factors on hair growth stimulation in laboratory and animal models, suggesting their potential as therapeutic agents for hair loss treatment.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
Adipose-derived stem cells (ADSCs) and their secretory factors were found to stimulate hair growth in various settings, including in vitro, ex vivo, and in vivo. The conditioned media of ADSCs (ADSC-CM) increased the proliferation rate of human follicular cells and improved hair growth by protecting human dermal papilla cells from cytotoxic injury. Additionally, ADSC-CM induced the anagen phase and promoted hair growth in mice, as well as enhanced hair shaft elongation in ex vivo human hair organ cultures. These findings suggested that ADSC-derived proteins could serve as feasible clinical therapeutic agents for treating hair loss, given the accessibility of ADSCs as a source of mesenchymal stem cells.
