Adipose-Derived Stem Cells and Their Secretory Factors for Skin Aging and Hair Loss

The 2016 document highlights the potential of adipose-derived stem cells (ADSCs) and their secretory factors in treating skin aging and hair loss. ADSCs, which can be easily obtained and cultured, secrete cytokines and growth factors that aid in tissue regeneration. They have shown positive effects on skin aging, such as wound healing, wrinkle reduction, and melasma improvement. For hair loss, ADSC protein extract has been found to promote hair growth by influencing follicular cell cycles and protecting cells from damage. Studies mentioned include a large-scale pilot study with 235 patients showing improvements in skin conditions, and observational pilot studies with 27 female and 25 male patients with pattern hair loss, both demonstrating significant increases in hair density and thickness after treatment with ADSC protein extract. A split-scalp study with six male patients also showed increased hair count on the treated side. These findings suggest ADSCs could be effective for skin and hair treatments, but further research is needed to confirm these results.