Bilayer Silk Fibroin/Sodium Alginate Scaffold Delivered Human Umbilical Cord Mesenchymal Stem Cells to Enhance Skin Scarless Healing and Hair Follicle Regeneration with the IRE1/XBP1 Pathway Inhibition

    May 2023 in “ ACS Biomaterials Science & Engineering ”
    Zhaona Dou, Tong Qiu, Yimeng Ren, Xinyu Wang, Quan Wen, Ying Shen, Lin Wu, Lei Han, Tao Jiang, Xinke Xia
    TLDR The scaffold helps wounds heal without scars and promotes hair growth.
    The study developed a bilayer silk fibroin/sodium alginate (SF/SA) scaffold to deliver human umbilical mesenchymal stem cells (hUC-MSCs) for enhanced wound healing. The scaffold mimics the epidermal and dermal structures, supporting cell survival and stemness. In vivo tests on full-thickness defect wounds showed that the scaffold-loaded hUC-MSCs (M-SF/SA) outperformed local injections of hUC-MSCs by promoting macrophage polarization, regulating TGF-β and collagen, enhancing vascular regeneration, and preventing scar formation while promoting hair follicle regeneration. The treatment also significantly inhibited endoplasmic reticulum stress markers IRE1, XBP1, and CHOP, making the SF/SA scaffold an effective platform for scarless skin healing and hair follicle regeneration.
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