Bilayer Silk Fibroin/Sodium Alginate Scaffold Delivered Human Umbilical Cord Mesenchymal Stem Cells to Enhance Skin Scarless Healing and Hair Follicle Regeneration with the IRE1/XBP1 Pathway Inhibition

    Zhaona Dou, Tong Qiu, Yimeng Ren, Xinyu Wang, Quan Wen, Ying Shen, Lin Wu, Lei Han, Tao Jiang, Xinke Xia
    TLDR The scaffold helps wounds heal without scars and promotes hair growth.
    The study developed a bilayer silk fibroin/sodium alginate (SF/SA) scaffold to deliver human umbilical mesenchymal stem cells (hUC-MSCs) for enhanced wound healing. The scaffold mimics the epidermal and dermal structures, supporting cell survival and stemness. In vivo tests on full-thickness defect wounds showed that the scaffold-loaded hUC-MSCs (M-SF/SA) outperformed local injections of hUC-MSCs by promoting macrophage polarization, regulating TGF-β and collagen, enhancing vascular regeneration, and preventing scar formation while promoting hair follicle regeneration. The treatment also significantly inhibited endoplasmic reticulum stress markers IRE1, XBP1, and CHOP, making the SF/SA scaffold an effective platform for scarless skin healing and hair follicle regeneration.
    Discuss this study in the Community →

    Research cited in this study

    5 / 5 results

    Related Community Posts Join

    6 / 45 results

      community Just passed by a homeless guy!

      in Chat  190 upvotes 2 months ago
      Hair loss treatments include finasteride, minoxidil, alfatradiol, vitamins, red light therapy, ketoconazole shampoo, meditation, green tea, leg workouts, and silk pillows. Genetics is emphasized as the primary factor in hair health, with some humor about unconventional methods like drug use affecting hair loss.

      community My Story + Products other than Finasteride and Minoxidil that saved me

      in Finasteride/Dutasteride  25 upvotes 1 year ago
      A user shared their hair loss journey, starting at age 18 and leading to depression and insecurity. They found improvement with finasteride and minoxidil after two years, and also recommended products like Mielle Rosemary Mint Growth Oil, Mielle Organics Rosemary Mint Strengthening Hair Masque, Kevin Murphy Hair Resort Spray, Brooklinen Silk Pillowcases, and It's a 10 Keratin Leave in Conditioner for maintaining hair quality.

      community General Advice for healthy hair: Tips and tricks?

      in Research/Science  10 upvotes 1 year ago
      The post and conversation are about hair loss treatments and tips for healthier hair, including using a dermaroller, taking vitamins (D, omega 3, zinc, magnesium), and using a silk pillowcase. The user also inquires about the effectiveness of aloe vera and oils for hair.

    Related Research

    1 / 1 results