Injectable Silver Nanoclusters-Based Hydrogel for Wound Healing by Eliminating Bacterial Infection and Promoting Tissue Regeneration
November 2020
in “
Chemical Engineering Journal
”
silver nanoclusters AgNCs@CH-MF chitosan mangiferin wound healing antibacterial activity cell proliferation skin appendages hair follicles capillaries injectability swelling degradability controlled release antibacterial agents in vivo experiments rat model bacterial infections wound recovery vascular regeneration tissue regeneration AgNCs antibacterial cell growth blood vessels injectable biodegradable infection blood vessel growth tissue growth
TLDR The hydrogel with silver and mangiferin helps heal wounds by killing bacteria and aiding skin and tissue repair.
The document presents a study on an injectable hydrogel, AgNCs@CH-MF, which incorporates silver nanoclusters and mangiferin molecules into a chitosan network for wound healing. The hydrogel exhibits strong antibacterial activity against various bacteria, promotes cell proliferation, and supports the regeneration of skin appendages like hair follicles and capillaries. It is characterized by its injectability, adequate swelling, good degradability, and controlled release of antibacterial agents. In vivo experiments on a rat model with skin flap wounds showed that the hydrogel effectively eliminated bacterial infections and facilitated rapid wound recovery, outperforming controls. The study concludes that AgNCs@CH-MF hydrogel is highly effective for wound treatment, with significant potential for bacterial killing and infection elimination, as well as promoting vascular and tissue regeneration. The sample size for the in vivo rat model and the cytotoxicity experiments was not specified in the provided text.
