Curcumin/Fe-SiO2 Nano Composites with Multi-Synergistic Effects for Scar Inhibition and Hair Follicle Regeneration During Burn Wound Healing

May 2021 in “ Applied Materials Today ”

Zhaowenbin Zhang, Yu Zhang, Wenbo Li, Lingling Ma, Endian Wang, Min Xing, Yanling Zhou, Zhiguang Huan, Feng Guo, Chen Yang

TLDR New nano composite helps reduce scars and regrow hair during burn wound healing.

The study developed a new type of nano composite, Cur-Fe-mesoporous silica nanoparticles (Cur-Fe-SiO2, MFSC), which showed synergistic activity in both inhibiting scar hyperplasia and promoting hair follicle regeneration during burn wound healing. The released bioactive components such as SiO3²-, Fe³+ and Fe-Cur chelates showed multi-synergistic effects in both inhibiting scar hyperplasia and promoting hair follicle regeneration. The study suggests that the synergistic effects between ions and flavonoids can be used to increase the bioactivity of biomaterials, and design of nano composites with bioactive ions and flavonoids might be an effective approach to prepare materials for tissue regeneration. The study found that the MFSC composite membrane and hydrogel wound dressing can inhibit scars and promote hair follicle regeneration in animal models of full-thickness incision injury and third-degree burns.

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