Curcumin/Fe-SiO2 Nano Composites with Multi-Synergistic Effects for Scar Inhibition and Hair Follicle Regeneration During Burn Wound Healing
May 2021
in “
Applied Materials Today
”
Cur-Fe-SiO2 mesoporous silica nanoparticles SiO3²- Fe³+ Fe-Cur chelates scar hyperplasia hair follicle regeneration burn wound healing bioactive ions flavonoids MFSC composite membrane hydrogel wound dressing full-thickness incision injury third-degree burns Curcumin Iron Silica Nano composites Wound healing Scar inhibition Hair growth Hydrogel
TLDR New nano composite helps reduce scars and regrow hair during burn wound healing.
The study developed a new type of nano composite, Cur-Fe-mesoporous silica nanoparticles (Cur-Fe-SiO2, MFSC), which showed synergistic activity in both inhibiting scar hyperplasia and promoting hair follicle regeneration during burn wound healing. The released bioactive components such as SiO3²-, Fe³+ and Fe-Cur chelates showed multi-synergistic effects in both inhibiting scar hyperplasia and promoting hair follicle regeneration. The study suggests that the synergistic effects between ions and flavonoids can be used to increase the bioactivity of biomaterials, and design of nano composites with bioactive ions and flavonoids might be an effective approach to prepare materials for tissue regeneration. The study found that the MFSC composite membrane and hydrogel wound dressing can inhibit scars and promote hair follicle regeneration in animal models of full-thickness incision injury and third-degree burns.
