Design of a Multifunctional Biomaterial Inspired by Ancient Chinese Medicine for Hair Regeneration in Burned Skin

    March 2020 in “ ACS Applied Materials & Interfaces ”
    Zhaowenbin Zhang, Qiuxia Dai, Yu Zhang, Hui Zhuang, Endian Wang, Qing Xu, Lingling Ma, Chengtie Wu, Zhiguang Huan, Feng Guo, Jiang Chang
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    TLDR The new biomaterial inspired by ancient Chinese medicine effectively promotes hair growth and heals wounds in burned skin.
    The document from March 2, 2020, details a study on a novel biomaterial inspired by ancient Chinese medicine, designed to promote hair regeneration and wound healing in burned skin. The biomaterial, a fibrous membrane composed of polycaprolactone (PCL), quercetin (Qu), and cuprorivaite (CaCuSi4O10), was found to release Qu and Cu ions, which synergistically stimulated hair follicle regeneration and wound healing. The study involved in vitro cell studies and in vivo experiments using a rat model with 80 rats divided into 5 groups. The P/Qu/Cup membrane showed increased antibacterial activity, enhanced proliferative capacity and migration ability of cells crucial for hair follicle regeneration and blood vessel formation, and contributed to collagen deposition and tissue regeneration. The study concluded that the P/Qu/Cup composite membrane effectively stimulates cellular activities necessary for tissue regeneration, demonstrating the potential of using traditional Chinese medicine components in regenerative medicine. The number of human participants was not mentioned, as the study focused on material design and animal models.
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