Building and Maintaining the Skin

    Ya‐Chieh Hsu, Elaine Fuchs
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    TLDR Three types of stem cells help maintain and repair skin, responding to health and environmental changes.
    The document "Building and Maintaining the Skin" discusses the role of three types of stem cells in maintaining and repairing the skin: epidermal stem cells, hair follicle stem cells, and melanocyte stem cells. Epidermal stem cells maintain the stratified epidermis, hair follicle stem cells drive the cyclic growth of hair follicles, and melanocyte stem cells regenerate pigment-producing melanocytes that color the skin and hair. These stem cells reside in complex microenvironments, or "niches", which consist of diverse cellular repertoires that enable stem cells to rejuvenate tissues during homeostasis and regenerate them upon injury. The document also highlights that skin stem cells can sense and respond to changes in organismal health or external changes, and that signals can be transmitted at the local level to enable skin stem cells to tailor their actions to suit the particular occasion and optimize fitness.
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