Lymphatic Vessels Interact Dynamically with the Hair Follicle Stem Cell Niche During Skin Regeneration In Vivo

    September 2019 in “ The EMBO Journal ”
    Daniel Peña-Jiménez, Sílvia Fontenete, Diego Megı́as, Coral Fustero‐Torre, Osvaldo Graña‐Castro, Donatello Castellana, Robert Loewe, Mirna Pérez-Moreno
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    Studysummary This study found that lymphatic vessels in mice are important for hair follicle development and organization, as their depletion blocks hair growth. Our plain-language summary of this paper — not a Tressless recommendation.
    In the 2019 study by Daniel Peña-Jimenez et al., researchers explored the relationship between lymphatic vessels (LVs) and hair follicle stem cell (HFSC) niches in mice during skin regeneration. They found that LVs are closely associated with the HF bulge and interconnect neighboring follicles, with their distribution and expansion being dependent on HFSC activity. LVs transiently expand in response to HFSC activation, which is associated with gene expression changes related to LV reorganization. The ablation of LVs resulted in inhibited hair follicle growth, suggesting that LVs are crucial for HF development and cycling. The study concluded that LVs are integral components of the HFSC niche, contributing to skin regeneration and coordinating tissue-level connections. The number of mice used in specific experiments was mentioned as n = 3 or n = 3-4, indicating the sample size for those particular analyses.
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