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GlossaryHair Follicle Stem Cell Niche (HFSC Niche)

specialized microenvironment regulating hair follicle stem cells

The Hair Follicle Stem Cell Niche, also known as the HFSC Niche, is a specialized microenvironment within the hair follicle that houses and regulates hair follicle stem cells. This niche provides the necessary signals and support to maintain stem cell function, enabling the cyclical growth, rest, and shedding phases of hair. It plays a crucial role in hair regeneration and repair, making it a key area of interest in studies related to hair loss and regenerative medicine.

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research Lymphatic Vessels Interact Dynamically with the Hair Follicle Stem Cell Niche During Skin Regeneration In Vivo

44 citations, September 2019 in “The EMBO Journal”

Lymphatic vessels are essential for hair follicle growth and skin regeneration.

research The Stem Cell Quiescence and Niche Signaling Is Disturbed in the Hair Follicle of the Hairpoor Mouse, an MUHH Model Mouse

2 citations, May 2022 in “Stem cell research & therapy”

Disrupted stem cell signals in hairpoor mice cause hair loss.

research Sphingolipid Metabolism Orchestrates the Establishment of the Adult Hair Follicle Stem Cell Niche to Control Skin Homeostasis

January 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

A specific enzyme is essential for proper hair follicle stem cell development and healthy skin.

research The Stem Cell Quiescence and Niche Signaling Is Disturbed in the Hair Follicle of the Hairpoor Mouse, an MUHH Model Mouse

October 2021 in “Research Square (Research Square)”

Hair follicle stem cells in hairpoor mice are disrupted, causing hair loss.

research A Family Business: Stem Cell Progeny Join the Niche to Regulate Homeostasis

254 citations, January 2012 in “Nature Reviews Molecular Cell Biology”

Stem cell offspring help control their parent stem cells, affecting tissue health, healing, and cancer.

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community 21 y/o M, 3 month amazing progress on min and topical fin, I want to share my success story.

in Progress Pictures 141 upvotes 3 years ago

A 21-year-old male who has been suffering from hair loss since he was 17, and has made great progress with a combination of minoxidil and finasteride topical solutions. They discussed the efficacy of microneedling for sensitive scalps as well.

community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

in Research/Science 198 upvotes 2 days ago

PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

community Horrible news, Stemson Therapeutics has shut down

in Technology 193 upvotes 1 week ago

Stemson Therapeutics has shut down, disappointing those seeking a hair loss cure. Current treatments like minoxidil, finasteride, and dutasteride are discussed, with some users experiencing side effects and exploring alternatives like PP405.