Organ-Level Quorum Sensing Directs Regeneration in Hair Stem Cell Populations

    April 2015 in “ Cell ”
    Chih-Chiang Chen, Lei Wang, Maksim V. Plikus … Cheng‐Ming Chuong
    Studysummary This study found that patterned hair plucking in mice triggers a collective regeneration response in nearby unplucked hair follicles via a quorum sensing mechanism involving immune signaling.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on cell.com →
    Discuss this study in the Community →

    Research cited in this study 12

    1. Stress-Induced Production of Chemokines by Hair Follicles Regulates the Trafficking of Dendritic Cells in Skin Nature Immunology · 2012
    2. Brief Report: Requirement of TACE/ADAM17 for Hair Follicle Bulge Niche Establishment Stem Cells · 2012
    3. Physiological Regeneration of Skin Appendages and Implications for Regenerative Medicine Physiology · 2012
    4. Multi-Layered Environmental Regulation on the Homeostasis of Stem Cells: The Saga of Hair Growth and Alopecia Journal of Dermatological Science · 2012
    5. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011
    6. Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells Science · 2011
    7. Receptor Activator of NF-κB Stimulates the Proliferation of Epithelial Cells of the Epidermo-Pilosebaceous Unit Proceedings of the National Academy of Sciences of the United States of America · 2011
    8. Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010
    9. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    10. Involvement of the Edar Signaling in the Control of Hair Follicle Involution (Catagen) ˜The œAmerican journal of pathology · 2006
    11. Defining the Impact of Beta-Catenin/Tcf Transactivation on Epithelial Stem Cells Genes & development · 2005
    12. Studies of Normal Moult and Artificially Induced Regeneration of Pelage in Peromyscus The journal of experimental zoology · 1918