Receptor Activator of NF-κB Stimulates the Proliferation of Epithelial Cells of the Epidermo-Pilosebaceous Unit

    March 2011 in “ Proceedings of the National Academy of Sciences of the United States of America ”
    Vincent Duhéron, Estelle Hess, Monique Duval, Marion Décossas, Beatriz Castañeda, Jennifer Elisabeth Klöpper, Leonela Amoasii, Jean-Baptiste Barbaroux, Ifor R. Williams, Hideo Yagita, Josef Penninger, Yongwon Choi, Frédéric Lézot, Richard Groves, Ralf Paus, Christopher G. Mueller
    Image
    Studysummary This study found that RANK-RANKL signaling regulates hair renewal and epidermal homeostasis in mice, revealing its role in initiating hair growth cycles and maintaining skin cell activity. Our plain-language summary of this paper — not a Tressless recommendation.
    The study demonstrated that the receptor activator of NF-κB (RANK) played a crucial role in the proliferation of epithelial cells within the epidermo-pilosebaceous unit, particularly in hair follicle (HF) cycling and epidermal homeostasis. Mice deficient in RANK ligand (RANKL) were unable to initiate a new growth phase of the hair cycle, resulting in arrested epidermal homeostasis. Conversely, transgenic mice overexpressing RANK or those administered recombinant RANKL showed activation of the hair cycle and epidermal growth. RANK was expressed by hair follicle germ and bulge stem cells, as well as epidermal basal cells, which are essential for the renewal of the epidermo-pilosebaceous unit. The study concluded that RANK-RANKL signaling was critical for hair renewal and epidermal homeostasis, linking these two processes.
    Discuss this study in the Community →

    Research cited in this study

    15 / 15 results