Brief Report: Requirement of TACE/ADAM17 for Hair Follicle Bulge Niche Establishment

    June 2012 in “ Stem Cells ”
    Keisuke Nagao, Tetsuro Kobayashi, Manabu Ohyama … Masayuki Amagai
    Studysummary This study found that depletion of TACE in mouse hair follicles led to impaired stem cell maintenance and hair loss, implicating TACE and EGFR signaling in hair follicle stem cell homeostasis.
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    Research cited in this study 6

    1. Canine Follicle Stem Cell Candidates Reside in the Bulge and Share Characteristic Features with Human Bulge Cells ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2010
    2. Persistent Hair Growth During Treatment With the EGFR Inhibitor Erlotinib Dermatology Online Journal · 2009
    3. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    4. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003
    5. Tcf3 and Lef1 Regulate Lineage Differentiation of Multipotent Stem Cells in Skin Genes & Development · 2001
    6. Genetically Null Mice Reveal a Central Role for Epidermal Growth Factor Receptor in the Differentiation of the Hair Follicle and Normal Hair Development PubMed · 1997