Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges

March 2014 in “ BioEssays ”

Talveen S. Purba, Iain S. Haslam, Enrique Poblet, Francisco Jiménez, Alberto Gandarillas, Ander Izeta, Ralf Paus

Studysummary This review examines current knowledge on human epithelial hair follicle stem cells, their markers, and outlines challenges in translating findings from murine studies to human research, but does not report new experimental results.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The 2014 document reviews the knowledge on human epithelial hair follicle stem cells (eHFSCs) and their progeny, emphasizing the biological and clinical significance of these cells in hair follicle cycling, alopecia, and regenerative medicine. It discusses the challenges in translating findings from mouse models to human physiology due to differences in stem cell markers and behavior. The review highlights the need for accurate human eHFSC markers, mentioning Keratin 15 and 19, CD200, CD34, PHLDA1, and EpCAM/Ber-EP4 as potential markers, but also notes the complexity of their expression patterns. It points out the diminished stem cell populations in androgenetic alopecia and the necessity for advanced technologies like RNA sequencing and mass cytometry to better understand eHFSC heterogeneity. The document calls for more research to close the translational gap and develop treatments for hair disorders and skin cancer, acknowledging the support of various grants for the work discussed.

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