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    Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges

    March 2014 in “ BioEssays ”
    Talveen S. Purba, Iain S. Haslam, Enrique Poblet … Ralf Paus
    Studysummary This review examines current knowledge on human epithelial hair follicle stem cells, their markers, and outlines challenges in translating findings from murine studies to human research, but does not report new experimental results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 58

    1. At the Dawn of Hair Research – Testing the Limits of Hair Follicle Regeneration Experimental Dermatology · 2014
    2. Generation of Folliculogenic Human Epithelial Stem Cells from Induced Pluripotent Stem Cells Nature communications · 2014
    3. Beta-1 Integrin Signaling Maintains Human Epithelial Progenitor Cell Survival In Situ and Controls Proliferation, Apoptosis, and Migration of Their Progeny PLoS ONE · 2013
    4. Stem Cell Dynamics in the Hair Follicle Niche Seminars in Cell & Developmental Biology · 2013
    5. Protection Against Chemotherapy-Induced Alopecia: Targeting ATP-Binding Cassette Transporters in the Hair Follicle Trends in pharmacological sciences · 2013
    6. Spatial Organization Within a Niche as a Determinant of Stem-Cell Fate Nature · 2013
    7. Keratin K15 as a Biomarker of Epidermal Stem Cells International Journal of Molecular Sciences · 2013
    8. Lichen Planopilaris Is Characterized By Immune Privilege Collapse Of The Hair Follicle's Epithelial Stem Cell Niche The Journal of Pathology · 2013
    9. Recent Advances in the Epidermal Growth Factor Receptor/Ligand System Biology on Skin Homeostasis and Keratinocyte Stem Cell Regulation Journal of Dermatological Science · 2013
    10. Brg1 Governs a Positive Feedback Circuit in the Hair Follicle for Tissue Regeneration and Repair Developmental Cell · 2013
    11. Drug Delivery to Hair Follicles Expert opinion on drug delivery · 2013
    12. Hopx Expression Defines a Subset of Multipotent Hair Follicle Stem Cells and a Progenitor Population Primed to Give Rise to K6+ Niche Cells Development · 2013
    13. Human Hair Follicle Stem/Progenitor Cells Express Hypoxia Markers Journal of Investigative Dermatology · 2013
    14. Pathobiology of Chemotherapy-Induced Hair Loss The Lancet Oncology · 2013
    15. Competitive Balance of Intrabulge BMP/Wnt Signaling Reveals a Robust Gene Network Ruling Stem Cell Homeostasis and Cyclic Activation Proceedings of the National Academy of Sciences · 2013
    16. Lineage Tracing of Hair Follicle Stem Cells in Epidermal Whole Mounts Methods in molecular biology · 2013
    17. A Matter of Life and Death: Self-Renewal in Stem Cells EMBO Reports · 2012
    18. Autoimmune Disease Induction in a Healthy Human Organ: A Humanized Mouse Model of Alopecia Areata Journal of Investigative Dermatology · 2012
    19. Epithelial Stem Cells And Implications For Wound Repair Seminars in Cell & Developmental Biology · 2012
    20. Mutant Laboratory Mice With Abnormalities in Hair Follicle Morphogenesis, Cycling, and Structure: An Update Journal of Dermatological Science · 2012
    21. Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling Seminars in Cell & Developmental Biology · 2012
    22. Hairy Tale of Signaling in Hair Follicle Development and Cycling Seminars in cell & developmental biology · 2012
    23. Brief Report: Requirement of TACE/ADAM17 for Hair Follicle Bulge Niche Establishment Stem Cells · 2012
    24. Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Investigative Dermatology · 2012
    25. A Family Business: Stem Cell Progeny Join the Niche to Regulate Homeostasis Nature Reviews Molecular Cell Biology · 2012
    26. Identification of Telogen Markers Underscores That Telogen Is Far from a Quiescent Hair Cycle Phase ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2011
    27. Genome-Wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage Cell stem cell · 2011
    28. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011
    29. Spermidine Promotes Human Hair Growth and Is a Novel Modulator of Human Epithelial Stem Cell Functions PLOS ONE · 2011
    30. Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells Cell stem cell · 2011
    31. Melanocyte Stem Cells: A Melanocyte Reservoir in Hair Follicles for Hair and Skin Pigmentation Pigment Cell & Melanoma Research · 2011
    32. Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells Journal of Clinical Investigation · 2011
    33. Involvement of the Bulge Region with Decreased Expression of Hair Follicle Stem Cell Markers in Senile Female Cases of Alopecia Areata JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2010
    34. Morphometric Analysis of the Human Scalp Hair Follicle: Practical Implications for the Hair Transplant Surgeon and Hair Regeneration Studies Dermatologic Surgery · 2010
    35. The Pathogenesis of Primary Cicatricial Alopecias The American Journal of Pathology · 2010
    36. Endocrine Controls of Primary Adult Human Stem Cell Biology: Thyroid Hormones Stimulate Keratin 15 Expression, Apoptosis, and Differentiation in Human Hair Follicle Epithelial Stem Cells In Situ and In Vitro European Journal of Cell Biology · 2010
    37. Differential Expression of Stem Cell Markers in Human Follicular Bulge and Interfollicular Epidermal Compartments Histochemistry and Cell Biology · 2010
    38. Prolactin: A Novel Neuroendocrine Regulator of Human Keratin Expression In Situ The FASEB Journal · 2010
    39. Hedgehog Signaling Maintains Hair Follicle Stem Cell Phenotype in Young and Aged Human Skin Aging Cell · 2009
    40. Nonviral In Situ Green Fluorescent Protein Labeling and Culture of Primary, Adult Human Hair Follicle Epithelial Progenitor Cells Stem Cells · 2009
    41. Methods in Hair Research: How to Objectively Distinguish Between Anagen and Catagen in Human Hair Follicle Organ Culture Experimental Dermatology · 2009
    42. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    43. Lentiviral Vector-Mediated Gene Transfer to Human Hair Follicles Journal of Investigative Dermatology · 2009
    44. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    45. Stem Cell Markers (Cytokeratin 15, CD34, and Nestin) in Primary Scarring and Nonscarring Alopecia British Journal of Dermatology · 2009
    46. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    47. Markers to Evaluate the Quality and Self-Renewing Potential of Engineered Human Skin Substitutes In Vitro and After Transplantation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2008
    48. Nfatc1 Balances Quiescence and Proliferation of Skin Stem Cells Cell · 2008
    49. An Extended Epidermal Response Heals Cutaneous Wounds in the Absence of a Hair Follicle Stem Cell Contribution ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2007
    50. The Hair Follicle as an Estrogen Target and Source Endocrine Reviews · 2006
    51. The Cell-Surface Marker MTS24 Identifies a Novel Population of Follicular Keratinocytes With Characteristics of Progenitor Cells Development · 2006
    52. Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2005
    53. Ber-EP4 Antigen Is a Marker for a Cell Population Related to the Secondary Hair Germ Experimental Dermatology · 2004
    54. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003
    55. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003
    56. A Role for p75 Neurotrophin Receptor in the Control of Apoptosis-Driven Hair Follicle Regression The FASEB Journal · 2000
    57. Keratin 19 as a Biochemical Marker of Skin Stem Cells In Vivo and In Vitro: Localization and Variation with Age and Culture Stage Journal of Cell Science · 1996
    58. Human Hair Growth In Vitro Journal of Cell Science · 1990

    Related research 7

    1. Characterization and Expression Analysis of the Hair Keratin Associated Protein KAP26.1 British Journal of Dermatology · 2008
    2. Hair Follicle-Specific Keratins And Their Diseases Experimental cell research · 2007
    3. Keratins of the Human Hair Follicle International review of cytology · 2005
    4. Hair Follicle Differentiation And Regulation The International Journal of Developmental Biology · 2004
    5. Hair Keratin Pattern in Human Hair Follicles Grown In Vitro Experimental dermatology · 2003
    6. Formation and Structure of Human Hair Birkhäuser Basel eBooks · 1995
    7. The Extraction And Characterization Of Human Nail Keratin Journal of Dermatological Science · 1991