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GlossaryHair Follicle Epithelial Stem Cells (eHFSCs)

specialized cells that regenerate and produce new hair

Hair Follicle Epithelial Stem Cells are specialized cells located in the hair follicle that have the ability to regenerate and produce new hair. These cells play a crucial role in the growth cycle of hair, as they can differentiate into various cell types needed for hair formation and repair, making them essential for maintaining healthy hair and potentially treating conditions like alopecia.

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research Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges

106 citations, March 2014 in “BioEssays”

We need more research to better understand human hair follicle stem cells for improved treatments for hair loss and skin cancer.

research Activation of the Integrated Stress Response in Human Hair Follicles

June 2024 in “PLoS ONE”

Blocking the Mitochondrial Pyruvate Carrier causes stress in hair follicles, which can be reduced by an ISR inhibitor.

Revealing Novel Insights on How Oral Supplementation With Collagen Peptides May Prevent Hair Loss: Lessons From the Human Hair Follicle Organ Culture

research Revealing Novel Insights on How Oral Supplementation With Collagen Peptides May Prevent Hair Loss: Lessons From the Human Hair Follicle Organ Culture

March 2024 in “Journal of functional foods”

Collagen peptides from marine and bovine sources may help prevent hair loss by affecting hair follicle stem cells differently.

research Understanding Immune Privilege in an Inducible Mouse Model of Primary Cicatricial Alopecia

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

The study found that a key immune pathway protecting hair follicles is reduced in a mouse model of scarring hair loss.

research Environmental Pathobiology of Frontal Fibrosing Alopecia: Does Linalool Promote FFA Development and Progression by Inducing Epithelial Hair Follicle Stem Cell Damage and MICA Expression in the Bulge?

September 2022

Linalool in personal care products may worsen frontal fibrosing alopecia by damaging hair follicle stem cells and triggering harmful immune responses.

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community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.