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Glossary PHLDA1

gene linked to hair follicle development and hair loss

PHLDA1 (Pleckstrin Homology-Like Domain, Family A, Member 1) is a gene that encodes a protein involved in cell survival and apoptosis (programmed cell death). In the context of hair biology, PHLDA1 has been linked to hair follicle development and cycling, and its expression is often studied in relation to conditions like alopecia (hair loss).

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research Skin tumors with matrical differentiation: lessons from hair keratins, beta‐catenin and PHLDA‐1 expression

47 citations , February 2014 in “Journal of Cutaneous Pathology”

This study found that nuclear beta-catenin, LEF1, and PHLDA1 expression was conserved in matrical tumors, suggesting a shared tumorigenesis process involving Wnt pathway activation.

research Characterization and isolation of stem cell-enriched human hair follicle bulge cells

550 citations , December 2005 in “The Journal of clinical investigation/The journal of clinical investigation”

This study found that bulge cells marked by CD200+ in human hair follicles show high colony-forming efficiency, suggesting successful enrichment of keratinocyte stem cells.

Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges

research Human epithelial hair follicle stem cells and their progeny: Current state of knowledge, the widening gap in translational research and future challenges

106 citations , March 2014 in “BioEssays”

This review examines current knowledge on human epithelial hair follicle stem cells, their markers, and outlines challenges in translating findings from murine studies to human research, but does not report new experimental results.

research Clinicopathologic study of 90 cases of trichofolliculoma

19 citations , September 2016 in “Journal of the European Academy of Dermatology and Venereology”

This article is a letter discussing a clinicopathologic study of 90 cases of trichofolliculoma and reports no new results.

Expression Patterns of Gli-1, Pleckstrin Homology-Like Domain, Family A, Member 1, Transforming Growth Factor-β1/β2, and p63 in Sebaceous and Follicular Tumors

research Expression Patterns of Gli-1, Pleckstrin Homology-Like Domain, Family A, Member 1, Transforming Growth Factor-β1/β2, and p63 in Sebaceous and Follicular Tumors

8 citations , January 2014 in “Annals of Dermatology”

This study found that TGF-β1 expression in follicular tumors correlates with differentiation degree and suggests its potential role alongside p63 in differentiating between sebaceous and follicular tumors.

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