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GlossaryPHLDA1

gene linked to hair follicle development and hair loss

PHLDA1 (Pleckstrin Homology-Like Domain, Family A, Member 1) is a gene that encodes a protein involved in cell survival and apoptosis (programmed cell death). In the context of hair biology, PHLDA1 has been linked to hair follicle development and cycling, and its expression is often studied in relation to conditions like alopecia (hair loss).

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research Skin Tumors With Matrical Differentiation: Lessons From Hair Keratins, Beta-Catenin and PHLDA1 Expression

47 citations , February 2014 in “Journal of Cutaneous Pathology”

Matrical tumors share a common growth mechanism involving the Wnt pathway and consistent PHLDA1 expression.

research Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells

550 citations , December 2005 in “The Journal of clinical investigation/The journal of clinical investigation”

Researchers successfully isolated and identified key markers of stem cell-enriched human hair follicle bulge cells.

Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges

research Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges

106 citations , March 2014 in “BioEssays”

We need more research to better understand human hair follicle stem cells for improved treatments for hair loss and skin cancer.

research Clinicopathologic Study of 90 Cases of Trichofolliculoma

19 citations , September 2016 in “Journal of the European Academy of Dermatology and Venereology”

Trichofolliculoma is a unique benign tumor mainly affecting middle-aged adults' faces, often misdiagnosed without histopathology.

Cutaneous Lymphadenoma Is a Distinct Trichoblastoma-like Lymphoepithelial Tumor With Diffuse Androgen Receptor Immunoreactivity, Notch1 Ligand in Reed-Sternberg-like Cells, and Common EGFR Somatic Mutations

research Cutaneous Lymphadenoma Is a Distinct Trichoblastoma-like Lymphoepithelial Tumor With Diffuse Androgen Receptor Immunoreactivity, Notch1 Ligand in Reed-Sternberg-like Cells, and Common EGFR Somatic Mutations

4 citations , May 2021 in “The American Journal of Surgical Pathology”

Cutaneous Lymphadenoma is a unique skin tumor with specific protein markers and common gene mutations that may cause continuous cell growth.

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