Genetically Null Mice Reveal a Central Role for Epidermal Growth Factor Receptor in the Differentiation of the Hair Follicle and Normal Hair Development

    June 1997 in “ PubMed ”
    Laura A. Hansen, Natalie Alexander, Margaret E. Hogan … Stuart H. Yuspa
    Studysummary In this study, disrupting the epidermal growth factor receptor in mice led to abnormal hair and skin development, characterized by disorganized hair follicles and systemic disease, providing a model for understanding EGFR's role in skin biology.
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    Research cited in this study 14

    1. Expression of a Dominant Negative Mutant of Epidermal Growth Factor Receptor in the Epidermis of Transgenic Mice Elicits Striking Alterations in Hair Follicle Development and Skin Structure. The EMBO Journal · 1995
    2. Cutaneous Ultrastructural Features of the Flaky Skin (Fsn) Mouse Mutation The Journal of Dermatology · 1995
    3. Hair Follicle Companion Layer: Reacquainting an Old Friend ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1995
    4. Sequence and Expression of Murine Type I Hair Keratins mHa2 and mHa3 Experimental Cell Research · 1994
    5. Isolation and Characterization of a Novel Hair Follicle-Specific Gene, Hacl-1 Journal of Investigative Dermatology · 1994
    6. Mice With a Null Mutation of the TGFα Gene Have Abnormal Skin Architecture, Wavy Hair, and Curly Whiskers and Often Develop Corneal Inflammation Cell · 1993
    7. Localization of Epidermal Growth Factor Immunoreactivity in Sheep Skin During Wool Follicle Development Journal of Investigative Dermatology · 1992
    8. Transgenic Mice Provide New Insights Into the Role of TGF-Alpha During Epidermal Development and Differentiation Genes & Development · 1991
    9. Immunolocalization of Epidermal Growth Factor Receptors in Normal Developing Human Skin Journal of Investigative Dermatology · 1990
    10. Comparison of Epidermal Growth Factor Binding and Receptor Distribution in Normal Human Epidermis and Epidermal Appendages Journal of Investigative Dermatology · 1984
    11. Distribution of Epidermal Growth Factor Receptors in Rat Tissues During Embryonic Skin Development, Hair Formation, and the Adult Hair Growth Cycle Journal of Investigative Dermatology · 1984
    12. Distribution and Number of Epidermal Growth Factor Receptors in Skin Is Related to Epithelial Cell Growth Developmental Biology · 1983
    13. Epidermal Growth Factor Delays Development of Epidermis and Hair Follicles in Mice During First Coat Growth The Anatomical Record · 1983
    14. Effects of Epidermal Growth Factor on Hair Growth in the Mouse Journal of Endocrinology · 1981

    Related research 8

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    3. Miz1 Is Required for Hair Follicle Structure and Hair Morphogenesis Journal of cell science · 2007
    4. Keratin 16 Expression Defines a Subset of Epithelial Cells During Skin Morphogenesis and the Hair Cycle Journal of Investigative Dermatology · 2002
    5. Genetically Null Mice Reveal a Central Role for Epidermal Growth Factor Receptor in the Differentiation of the Hair Follicle and Normal Hair Development PubMed · 1997
    6. Overexpression of Insulin-Like Growth Factor-1 Induces Hyperplasia, Dermal Abnormalities, and Spontaneous Tumor Formation in Transgenic Mice Oncogene · 1997
    7. Expression of a Dominant Negative Mutant of Epidermal Growth Factor Receptor in the Epidermis of Transgenic Mice Elicits Striking Alterations in Hair Follicle Development and Skin Structure. The EMBO Journal · 1995
    8. The Dermal Papilla and Maintenance of Hair Growth 1988