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GlossaryLIM Homeobox 2 (Lhx2)

gene encoding a protein crucial for hair follicle development

LIM Homeobox 2 (Lhx2) is a gene that encodes a transcription factor, which is a type of protein that helps control the activity of other genes. It plays a crucial role in the development of various tissues, including the brain and hair follicles. In the context of hair, Lhx2 is essential for the proper formation and cycling of hair follicles, making it significant in studies related to hair growth and conditions like alopecia.

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research LHX2 Is a Direct NF-κB Target Gene That Promotes Primary Hair Follicle Placode Down-Growth

43 citations, January 2016 in “Development”

LHX2 is essential for hair follicle development, controlled by NF-κB and TGFβ2 signaling.

research Highly Upregulated Lhx2 in the Foxn1−/− Nude Mouse Phenotype Reflects a Dysregulated and Expanded Epidermal Stem Cell Niche

6 citations, May 2013 in “PloS one”

The Foxn1(-/-) nude mouse shows disrupted and expanded skin stem cell areas due to high Lhx2 levels.

research Downregulation of Lhx2 Markedly Impairs Wound Healing in Mouse Fetus

August 2022 in “Biomedicines”

Turning off the Lhx2 gene in mouse embryos leads to slower wound healing and scars.

research Author Response: Lhx2 as a Progenitor-Intrinsic Modulator of Sonic Hedgehog Signaling During Early Retinal Neurogenesis

October 2022

Lhx2 is a crucial regulator of the Sonic Hedgehog signaling in early mouse retinal development.

research Epithelial Stem Cells And Implications For Wound Repair

156 citations, October 2012 in “Seminars in Cell & Developmental Biology”

Different types of stem cells in hair follicles play unique roles in wound healing and hair growth, with some stem cells not originating from existing hair follicles but from non-hair follicle cells. WNT signaling and the Lhx2 factor are key in creating new hair follicles.

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