Targeted Self-Assembled Anti-NFκB AuNCs-Aptamer Nanoplatform for Precise Theranostics via Tailored Follicle Regeneration

    April 2025 in “ Materials Today Bio
    Xiangdong Lai, Xiaoyang Zhang, Jiejuan Lai, Weiwei Zhao, Zhongquan Song, Yuanyuan Chen, Miraj Ud din, Muhammad Faizan Munawer, Hui Jiang, Xiaohui Liu, Xuemei Wang
    TLDR A new treatment using gold nanoclusters can safely reduce unwanted hair growth.
    The study explores a novel therapeutic approach for hypertrichosis using a nanoplatform composed of self-assembled gold nanoclusters (AuNCs) and anti-NFκB aptamers. This method targets the NFκB-mediated inflammatory response to inhibit hair follicle regeneration. Conducted on C57BL/6 mice, the research demonstrated that the AuNCs-Aptamer complexes effectively targeted oxidative stress-damaged skin cells, reducing inflammatory markers and inhibiting hair growth without affecting surrounding areas. The study confirmed the biosafety of the complexes, showing no toxicity in major organs or blood parameters, and presents a promising strategy for managing hypertrichosis by avoiding the use of toxic transfection reagents.
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