MiR-199a-3p Regulates the PTPRF/β-Catenin Axis in Hair Follicle Development: Insights into the Pathogenic Mechanism of Alopecia Areata

    Jiankui Wang, Yuhao Ma, Tun Li, Jinnan Li, Xue Yang, Guoying Hua, Ganxian Cai, Han Zhang, Zhexi Liu, Keliang Wu, Xing‐Wang Deng
    TLDR miR-199a-3p controls hair growth and is linked to alopecia areata.
    The study explores the role of miR-199a-3p in hair follicle development and its connection to alopecia areata. Researchers found that miR-199a-3p targets PTPRF, activating the Wnt/β-catenin pathway, which is essential for hair growth. Experiments in lambs, mice, and HEK293T cells showed that overexpression of miR-199a-3p increased β-catenin activity, promoting hair follicle development, while suppression of miR-199a-3p inhibited these effects. The findings suggest miR-199a-3p as a potential therapeutic target for alopecia areata, with significant changes observed in immune-related and hair follicle development genes.
    Discuss this study in the Community →

    Research cited in this study

    18 / 18 results

    Related Community Posts Join

    6 / 23 results

      community Getting dutasteride in germany

      in Finasteride/Dutasteride  18 upvotes 5 months ago
      You can get dutasteride in Germany through the Teleclinic app, which sends a prescription to a nearby pharmacy. It costs around 18-19 euros for the prescription and 47 euros for 90 pills of Avodart 0.5.

      community Anyone Try Microneedling with Exosomes/AAPE?

      in Microneedling  2 upvotes 2 years ago
      User asks where to purchase exosomes/AAPE for microneedling hair loss treatment. Links to research on hair regeneration therapy, stem cell therapy, exosome therapy, and dermal exosomes provided.

      community Megadosing Koshine826(Pyrilutamide), my Plan.

      in Treatment  1 upvotes 3 months ago
      The user plans to use 1% Koshine826, 0.1% Alfatradiol, Minoxidil with Tretinoin, microneedling, and Stemoxydine for hair loss treatment. They expect significant recovery with this regimen.

      community Help in Germany to get recommended medicine

      in Finasteride/Dutasteride  5 upvotes 3 months ago
      A user in Germany is seeking advice on obtaining Dutasteride, Minoxidil, and Biotin for hair treatment before a hair transplant. They face difficulties getting prescriptions and are concerned about delays due to required exams.

    Related Research

    4 / 4 results