MiR-199a-3p Regulates the PTPRF/β-Catenin Axis in Hair Follicle Development: Insights into the Pathogenic Mechanism of Alopecia Areata

    Jiankui Wang, Yuhao Ma, Tun Li, Jinnan Li, Xue Yang, Guoying Hua, Ganxian Cai, Han Zhang, Zhexi Liu, Keliang Wu, Xing‐Wang Deng
    TLDR miR-199a-3p controls hair growth and is linked to alopecia areata.
    The study explores the role of miR-199a-3p in hair follicle development and its connection to alopecia areata. Researchers found that miR-199a-3p targets PTPRF, activating the Wnt/β-catenin pathway, which is essential for hair growth. Experiments in lambs, mice, and HEK293T cells showed that overexpression of miR-199a-3p increased β-catenin activity, promoting hair follicle development, while suppression of miR-199a-3p inhibited these effects. The findings suggest miR-199a-3p as a potential therapeutic target for alopecia areata, with significant changes observed in immune-related and hair follicle development genes.
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