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Glossary Immune-Related Genes

segments of DNA that regulate immune system responses

Immune-related genes are segments of DNA that play a crucial role in regulating the immune system's response to pathogens, such as bacteria and viruses. These genes help produce proteins that identify and attack foreign invaders, and variations in these genes can influence how effectively an individual's immune system functions.

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Research

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research Identification of immune microenvironment changes, immune-related pathways and genes in male androgenetic alopecia

September 2023 in “Medicine”

This study found increased infiltration of specific immune cells, such as γδ T cells and CD8+ T cells, in the bald scalp of male androgenetic alopecia patients, and identified four key immune-related genes potentially involved in hair loss development through interferon-γ signaling pathways.

research Transcriptional profiling in alopecia areata defines immune and cell cycle control related genes within disease-specific signatures

61 citations , September 2010 in “Genomics”

This study found distinct gene expression profiles in alopecia areata-affected skin, suggesting T-cell mediated immune responses and unique gene profiles between different stages of the disease.

research 806 Immune related gene expression analysis of de novo primary skin cancers in patients receiving immune checkpoint inhibitors for advanced cSCC

July 2024 in “Journal of Investigative Dermatology”

research Calcitonin gene‐related peptide (CGRP) may award relative protection from interferon‐γ‐induced collapse of human hair follicle immune privilege

47 citations , December 2011 in “Experimental Dermatology”

This study suggests that the neuropeptide CGRP may protect against, but not restore, IFNγ-induced collapse of hair follicle immune privilege in alopecia areata.

research Exomic Sequencing of Immune-Related Genes Reveals Novel Candidate Variants Associated with Alopecia Universalis

18 citations , January 2013 in “PLoS ONE”

This study identified several significant genetic variants associated with alopecia universalis, including a novel association with HLA-DRB5, which may play a hidden role in the disease.

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Community Join

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community Sharing what worked for me (PCOS related hair loss)

34 upvotes 2 years ago

A user with PCOS experienced hair loss and found success using a triple dose of O.N.E Omega by Pure Encapsulations after discovering low Omega fatty acids. Biotin provided minimal improvement, but the Omega supplement significantly restored hair.

community Federal Grant Cuts have impacted PP405 related research

459 upvotes 1 year ago

Federal funding cuts have delayed PP405 research, affecting hair loss treatment progress, though clinical trials will continue. The discussion highlights PP405's potential compared to minoxidil and finasteride and stresses the importance of government-funded research.

community I (diffuse thinner) would genuinely prefer having the Generic MPB hairloss

in Chat 35 upvotes 1 year ago

The conversation discusses struggles with diffuse thinning and hair loss treatments, including the use of dutasteride, minoxidil, and finasteride, with limited success. The original poster regrets having a hair transplant at 21 due to weak donor hair and ongoing thinning.

community Calling out diffuse thinners here -- Have you ruled out other factors?

in Treatment 54 upvotes 1 year ago

Diffuse hair loss is often linked to genetics but can also be due to health issues like thyroid problems and low vitamin or iron levels. Treatments include finasteride, minoxidil, and dutasteride, with some seeing improvements after addressing health issues.

community How is it possible for someone to be a non responder to ORAL minoxidil?

in Minoxidil 66 upvotes 2 years ago

Some individuals do not respond to oral minoxidil for hair loss, despite it generally working by improving blood flow to hair follicles. Factors like metabolism, drug interactions, and individual variations in the drug's activation may influence its effectiveness.

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Learn

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learn Vitamin D

Vitamin made in the skin from sunlight, also taken as a supplement

learn Thymosin Beta 4

learn Neem Oil

Oil from the neem tree, used in traditional remedies

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Experts

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Hair System Specialist
Jane Genesi
Marlton, PA, United States

Clinics

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TrichologyHair Loss Treatments
Centro Medico GenesySchio · IT

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Jane Genesi