Alopecia Areata in a Patient with WNT10A Heterozygous Ectodermal Dysplasia

    June 2021 in “ Dermatology Online Journal
    Regina Liu, Amy R. Vandiver, Nicole Harter, Marcia Hogeling
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    TLDR A girl with a rare genetic condition affecting hair and nails also developed a common type of hair loss, suggesting a possible genetic link.
    The document presents a case of a 9-year-old girl with WNT10A heterozygous ectodermal dysplasia, a rare condition affecting hair, teeth, nails, and sweat glands, who developed alopecia areata, a common form of hair loss in children. The patient had a lifelong history of poor hair and nail growth, and recently experienced patchy hair loss. This is the first reported case of alopecia areata in a patient with WNT10A heterozygous ectodermal dysplasia, suggesting the possibility of a shared genetic predisposition. The case emphasizes the importance of considering multiple pathways of hair loss in patients with underlying genetic defects.
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