Alopecia Areata: Treatment of Today and Tomorrow

    Pia Freyschmidt‐Paul, Rudolf Happle, Kevin J. McElwee, Rolf Hoffmann
    TLDR Contact sensitizers like DCP and SADBE are the most effective treatments for alopecia areata.
    The article reviewed treatments for alopecia areata (AA) as of 2003, emphasizing the need for controlled studies and long-term safety. It concluded that contact sensitizers like diphenylcyclopropenone (DCP) and squaric acid dibutylester (SADBE) were the most effective treatments, with response rates between 29%-78%, despite not being approved therapeutic substances. Topical corticosteroids were ineffective due to poor penetration, and systemic corticosteroids had unacceptable side effects. Future treatments might focus on immunosuppressive or immunomodulatory strategies targeting the autoimmune nature of AA or protecting hair follicles from inflammation.
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