Topical Liposome Delivery of Molecules to Hair Follicles in Mice

In 1997, Lingna Li and Robert M. Hoffman conducted a study that showed phosphatidylcholine liposomes could effectively deliver molecules like calcein and melanin to hair follicles in mice. The delivery was time-dependent and targeted, with minimal absorption into the dermis, epidermis, or bloodstream, suggesting a safe and effective method for treating hair disorders. The study also indicated that without liposomes, these molecules could not penetrate beyond the skin's outer layer. Additionally, unpublished data showed successful delivery to human hair follicles in cultured scalp tissue, supporting the potential use of this system in humans. The research, partly funded by the National Cancer Institute, highlighted the promise of liposome-based delivery systems for hair cycle study and hair disorder therapy without significant systemic side effects.