Utility of Azathioprine, Methotrexate, and Cyclosporine as Steroid-Sparing Agents in Chronic Alopecia Areata: A Retrospective Study of Continuation Rates in 138 Patients

    August 2020 in “ JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology ”
    Vivien Wai Yun Lai, Rodney Sinclair
    Studysummary This study found that most chronic alopecia areata patients treated with azathioprine, methotrexate, or cyclosporine continued treatment for at least 12 months, often requiring concurrent low-dose prednisolone.
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    Research cited in this study 19

    1. Cyclosporine for Moderate-to-Severe Alopecia Areata: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial of Efficacy and Safety Journal of the American Academy of Dermatology · 2019
    2. Treatment of Alopecia Areata: An Australian Expert Consensus Statement Australasian journal of dermatology · 2018
    3. Systemic Treatments for Alopecia Areata: A Systematic Review Australasian journal of dermatology · 2018
    4. Methotrexate for the Treatment of Pediatric Alopecia Areata Journal of dermatological treatment · 2017
    5. Efficacy and Safety of Methotrexate Combined with Low- to Moderate-Dose Corticosteroids for Severe Alopecia Areata Dermatology · 2016
    6. A Comparative Study of Oral Cyclosporine and Betamethasone Minipulse Therapy in the Treatment of Alopecia Areata Annals of dermatology/Annals of Dermatology · 2016
    7. Efficacy and Safety of Methotrexate in Alopecia Areata Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia · 2014
    8. Clinical Response to Combined Therapy of Cyclosporine and Prednisone ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2013
    9. Current Treatment of Alopecia Areata ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2013
    10. The Effect of Oral Cyclosporine in the Treatment of Severe Alopecia Areata Cutaneous and ocular toxicology · 2013
    11. British Association of Dermatologists’ Guidelines for the Management of Alopecia Areata 2012 British Journal of Dermatology · 2012
    12. Interest of High-Dose Pulse Corticosteroid Therapy Combined with Methotrexate for Severe Alopecia Areata: A Retrospective Case Series Dermatology · 2012
    13. Efficacy and Tolerability of Methotrexate in Severe Childhood Alopecia Areata British journal of dermatology/British journal of dermatology, Supplement · 2011
    14. Treatment of Persistent Alopecia Areata with Sulfasalazine International Journal of Dermatology · 2008
    15. Treatment of Severe Alopecia Areata: Combination Therapy Using Systemic Cyclosporine A with Low Dose Corticosteroids Annals of Dermatology · 2008
    16. Placebo-Controlled Oral Pulse Prednisolone Therapy in Alopecia Areata Journal of the American Academy of Dermatology · 2005
    17. Sulfasalazine for Alopecia Areata Journal of the American Academy of Dermatology · 2002
    18. Partial Response of Severe Alopecia Areata to Cyclosporine A Dermatology · 1999
    19. Alopecia Universalis Treated With Oral Cyclosporine A And Prednisolone: Immunologic Studies International Journal of Dermatology · 1992