Clinical Response to Combined Therapy of Cyclosporine and Prednisone
December 2013
in “
The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings
”
New to Alopecia Areata? There is a guide in the encyclopedia. Read the guide → Studysummary This case report describes a patient with severe alopecia areata and multiple autoimmune diseases who showed excellent hair regrowth after treatment with prednisone and cyclosporine, though she later developed hyperpigmentation.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
A 13-year-old female with severe alopecia areata, multiple autoimmune diseases, and Down syndrome showed poor response to topical treatments but some improvement with glucocorticoid injections. She had 85-90% scalp hair loss and was treated with oral prednisone and cyclosporine. Over 3 months, she experienced excellent hair regrowth and improved well-being. Prednisone was tapered and discontinued. Several months post-treatment, she developed hyperpigmentation consistent with confluent and reticulated papillomatosis, likely unrelated to her previous therapy. The case highlighted the potential effectiveness of combined cyclosporine and prednisone therapy for late-stage alopecia areata.
