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GlossaryMethotrexate (Trexall)

inhibits cell growth by blocking folic acid metabolism

Methotrexate (MTX) is a medication commonly used to treat certain types of cancer, autoimmune diseases like rheumatoid arthritis, and severe psoriasis. It works by inhibiting the metabolism of folic acid, which is necessary for the rapid growth of cells, thereby slowing down the proliferation of cancer cells and modulating the immune system.

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$Characteristics and Alternative Treatment Outcomes of Antimalarial-Refractory Cutaneous Lupus Erythematosus$

research Characteristics and Alternative Treatment Outcomes of Antimalarial-Refractory Cutaneous Lupus Erythematosus

16 citations , June 2017 in “JAMA Dermatology”

Thalidomide works best for skin lupus not helped by antimalarials, but has many side effects; other treatments are less effective, especially if patients also have systemic lupus.

research Lupus Erythematosus: Considerations About Clinical, Cutaneous, and Therapeutic Aspects

15 citations , January 2014 in “Anais Brasileiros de Dermatologia”

Lupus treatment requires a combination of drugs and therapies, with research needed for new options.

Utility of Azathioprine, Methotrexate, and Cyclosporine as Steroid-Sparing Agents in Chronic Alopecia Areata: A Retrospective Study of Continuation Rates in 138 Patients

research Utility of Azathioprine, Methotrexate, and Cyclosporine as Steroid-Sparing Agents in Chronic Alopecia Areata: A Retrospective Study of Continuation Rates in 138 Patients

12 citations , August 2020 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

Azathioprine is the most continued treatment for chronic alopecia areata over a year, often with added low-dose prednisolone.

research PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds

9 citations , June 2023 in “Cells”

Certain natural and synthetic compounds may help treat inflammatory skin diseases by targeting a specific signaling pathway.

research Shedding Light on Therapeutics in Alopecia and Their Relevance to COVID-19

7 citations , December 2020 in “Clinics in Dermatology”

Some alopecia treatments might help treat COVID-19, but more research is needed.

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