Alopecia Areata: Pathogenesis, Current Treatments, and Future Perspectives

March 2025 in “ Journal of Education Health and Sport ”

Karolina Wojciechowska, Maria Brzozowska, W. Wardal, Natalia Furlepa, Robert Rzenno, Marlena Matuszewska, Katarzyna Wicha, Natalia Sidz, Magdalena Tomaszewska, Wiktoria Jedlikowska

alopecia areata autoimmune disorder hair follicles T-cells topical therapies systemic therapies Janus kinase inhibitors JAK inhibitors stem cell-based therapies AA

TLDR Alopecia areata causes hair loss due to immune issues, and while new treatments show promise, no universally effective solution exists yet.

Alopecia areata (AA) is a chronic autoimmune disorder characterized by non-scarring hair loss due to immune dysregulation, specifically the destruction of hair follicles by autoreactive T-cells. Treatment options depend on the severity of the disease, with topical therapies used for limited hair loss and systemic therapies for more severe cases. Recent advancements in treatment include Janus kinase (JAK) inhibitors, which have shown promise in clinical trials for refractory AA, and emerging stem cell-based therapies. Despite these advancements, there remains a significant unmet medical need, as no universally effective treatment exists. Further research is essential to better understand the pathogenesis of AA and to develop more effective therapies.

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community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

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community Boys I am just a gonner. What on earth is my scalp even going through. Looks like world war 3. Pyril 3 months. Topical melitonin/progesterone/fin, dut, fin, oral min, laser trash, anus stimulation. Nothing. Donor area is decimated 😂.

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community I’m 14 years old and I’m losing more hair than my dad. I’ve gone to the doctor 2 times because of this and I’ve received no help. I’m starting to feel like It’s worthless and my hairs gonna look like this forever. I don’t know how anyone could help me but it’s always worth a shot.

in Treatment 4 years ago

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 4 months ago

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April 2019 in “International journal of research in dermatology”

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