TLDR Temporary ROS production in cultured human hair follicles promotes growth and stem cell activation.
The study demonstrated that transient, non-lethal endogenous ROS production in ex vivo cultured human hair follicles efficiently promoted the entry into the growth phase (anagen). This process involved the activation of the hair follicle stem cell niche, marked by the induction of stem cell differentiation markers (Ck15), increased cell proliferation, and sustained tissue growth. Additionally, it was associated with the expression of growth-related genes (Ccnd1) and the inhibition of Wnt signaling antagonists (Dkk1, Gsk3β). The findings suggested that ROS signaling intrinsically regulated the hair follicle stem cell niche independently of external signals.
426 citations
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,
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,
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2 citations
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February 2023 in “International journal of molecular sciences” Tetrathiomolybdate reduces hair growth marker in skin cells by boosting harmful oxygen molecules, but effects can be reversed.
