TLDR Lack of a certain enzyme causes hair to grey early by damaging stem cells, but an antioxidant can help prevent this.
This study examines the role of mitochondrial deoxyguanosine kinase (DGUOK) in hair pigmentation, finding that its depletion leads to premature hair greying due to the loss of melanocyte stem cells (MeSCs) and melanocytes. In Dguok knockout mice, decreased expression of mitochondrial DNA-encoded genes and increased reactive oxygen species (ROS) levels result in MeSC apoptosis. Treatment with N-acetylcysteine (NAC), an ROS inhibitor, restores MeSCs and reduces hair depigmentation. The research underscores the importance of DGUOK in maintaining mitochondrial function and hair pigmentation, suggesting potential therapeutic strategies for preventing hair greying.
The user is seeking alternatives to Minoxidil due to heart issues and is considering microneedling with topical melatonin, copper peptides, resveratrol+fisetin, or stemoxydine, which reportedly have minimal side effects. They are asking for information on the effectiveness of these treatments.
Microneedling and tretinoin may enhance minoxidil absorption for hair loss, but evidence on their effectiveness is limited. Iron supplements and broccoli sprouts are suggested for enzyme activation, but their impact on hair is unclear.
The conversation is about hair regrowth progress using a combination of treatments: dutasteride, minoxidil, RU58841, ketoconazole, and monthly microneedling. The user reports that microneedling and topical minoxidil had the most impact on their hairline.
A 23-year-old male has been experiencing hair loss since 2022 and has used minoxidil and dutasteride with reduced shedding but no hair regrowth. He is considering PRP with mesotherapy and red light therapy, GFC, or exosomes, with a preference for exosomes due to efficiency and a reputable clinic.
Oleic acid and microneedling are being explored for hair regrowth, but results are mixed. Addressing DHT and fibrosis is crucial, with treatments like finasteride, minoxidil, and scalp massage also discussed.
Adipose-derived stemcells with ATP improved hair regrowth in male and female mice with androgenetic alopecia. The most effective treatments were low dose stemcells with ATP for males and medium dose stemcells with non-liposomal ATP for females.
