Targeted Knockout of Beta-Catenin in Adult Melanocyte Stem Cells Using a Mouse Line, Dct::CreERT2, Results in Disrupted Stem Cell Renewal and Pigmentation Defects

    October 2020 in “ Journal of Investigative Dermatology ”
    Madeleine Le Coz, Zackie Aktary, Natsuki Watanabe … Lionel Larue
    Studysummary This study established that the Dct::CreERT2 mouse line is effective for targeting and studying adult melanocyte stem cells, contributing to the understanding of melanocyte biology and hair pigmentation.
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    Research cited in this study 5

    1. From Neural Crest Cells to Melanocytes: Cellular Plasticity During Development and Beyond Cellular and Molecular Life Sciences · 2019
    2. EdnrB Governs Regenerative Response of Melanocyte Stem Cells by Crosstalk with Wnt Signaling Cell Reports · 2016
    3. Any Route for Melanoblasts to Colonize the Skin Experimental Dermatology · 2016
    4. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration Cell · 2011
    5. Melanocyte Stem Cells: A Melanocyte Reservoir in Hair Follicles for Hair and Skin Pigmentation Pigment Cell & Melanoma Research · 2011

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