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GlossaryMelanocyte Stem Cells (McSCs)

specialized cells that develop into pigment-producing melanocytes

Melanocyte stem cells are specialized cells found in the hair follicles and skin that have the ability to develop into melanocytes, which are the cells responsible for producing melanin, the pigment that gives color to hair, skin, and eyes. These stem cells play a crucial role in the regeneration of melanocytes, helping to maintain pigmentation and potentially offering insights into treatments for conditions like vitiligo and age-related graying of hair.

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research Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration

260 citations, June 2011 in “Cell”

Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.

research EdnrB Governs Regenerative Response of Melanocyte Stem Cells by Crosstalk with Wnt Signaling

59 citations, April 2016 in “Cell Reports”

EdnrB signaling helps melanocyte stem cells regenerate and could be targeted to treat pigmentation issues.

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