CD34 Defines Melanocyte Stem Cell Subpopulations With Distinct Regenerative Properties

    April 2019 in “ PLOS genetics ”
    Sandeep S. Joshi, Bishal Tandukar, Pan Li … Thomas J. Hornyak
    Studysummary This study found that CD34- melanocyte stem cells regenerated pigmentation more efficiently, while CD34+ cells showed potential for neuron myelination, suggesting different therapeutic applications for each population.
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    Research cited in this study 10

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    2. Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges BioEssays · 2014
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    4. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration Cell · 2011
    5. Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells Cell stem cell · 2011
    6. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    7. Implanted Hair Follicle Stem Cells Form Schwann Cells That Support Repair of Severed Peripheral Nerves Proceedings of the National Academy of Sciences · 2005
    8. Multipotent Nestin-Positive, Keratin-Negative Hair-Follicle Bulge Stem Cells Can Form Neurons Proceedings of the National Academy of Sciences · 2005
    9. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003
    10. Do Hair Bulb Melanocytes Undergo Apoptosis During Hair Follicle Regression (Catagen)? ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998